Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice

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Salonurmi, T.; Parikka, M.; Kontusaari, S.; Pirila, E.; Munaut, Carine; Salo, T.; Tryggvason, K.;
(2004)
  • Subject: gene expression regulation | keratinocytes | matrix metalloproteinases | tissue inhibitor of metalloproteinase-1 | transgenic mice | : Biochemistry, biophysics & molecular biology [Life sciences] | : Biochimie, biophysique & biologie moléculaire [Sciences du vivant]

We have generated transgenic mice harboring the murine matrix metalloproteinase 9 (MMP-9) promoter cloned in front of human TIMP-1 cDNA. The transgenic mice were viable and fertile and exhibited normal growth and general development. During wound healing the mice were s... View more
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