Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene.
Jennings, J. E.; Georgitsi, M.; Holdaway, I.; Daly, Adrian; Tichomirowa, M.; Beckers, Albert; Aaltonen, Lauri A; Karhu, A.; Cameron, F. J.;
Subject: Adenoma/genetics | Adolescent | Adult | Australia | DNA/chemistry/genetics | Female | Genetic Variation | Germ-Line Mutation | Humans | Intracellular Signaling Peptides and Proteins/genetics | Male | New Zealand | Pedigree | Pituitary Neoplasms/genetics | Point Mutation | Polynesia/ethnology | Sequence Analysis, DNA | Young Adult | : Endocrinology, metabolism & nutrition [Human health sciences] | : Endocrinologie, métabolisme & nutrition [Sciences de la santé humaine]
OBJECTIVE: Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) were recently shown to confer a pituitary adenoma predisposition in patients with familial isolated pituitary adenomas (FIPA). We report a large Samoan FIPA kindred from Australia/New Zealan... View more