publication . Article . 2008

Optimization of Verapamil drug analysis by excitation-emission fluorescence in combination with second-order multivariate calibration.

João M. M. Leitão; Joaquim C. G. Esteves da Silva; Ana Jiménez Girón; Arsenio Muñoz de la Peña;
Open Access English
  • Published: 11 Mar 2008
  • Country: Portugal
Abstract
Abstract Excitation emission fluorescence matrices (EEMs) of Verapamil drug were obtained by direct and by derivatization fluorescence spectroscopy. The fluorescence excitation and emission wavelengths were displaced to longer wavelengths and the fluorescence intensity was enhanced upon derivation with respect to the native fluorescence of the drug. The complete EEM of the native fluorescence of the drug and of the derivatization product were rapidly acquired by using a charged-coupled device detector (CCD), which is advantageous in terms of speed in the analysis, with respect to the use of a conventional photomultiplier detector. The EEMs were analyzed by sever...
Subjects
free text keywords: Spectroscopy, Clinical Biochemistry, Social Sciences (miscellaneous), Biochemistry, Sociology and Political Science, Law, Clinical Psychology, Derivatization, chemistry.chemical_compound, chemistry, Detection limit, Fluorescence spectroscopy, Chromatography, Least squares, Detector, Pharmaceutical formulation, Standard addition, Analytical chemistry, Fluorescence
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