publication . Doctoral thesis . 2016

Characterization of KIR2DS1+ decidual Natural Killer cells in healthy and viral/bacterial – infected human pregnancy

Crespo, Ângela Pascoal da Costa;
Open Access English
  • Published: 18 Jan 2016
  • Country: Portugal
Abstract
Tese de doutoramento em Biociências, na área de especialização de Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra Human pregnancy is a challenge for the maternal immune system, which must maintain tolerance to a semi-foreign entity (the fetus) while keeping immunity against viral, bacterial and parasite infections. While the mechanisms involved in placental immune tolerance have been addressed for the last thirty years, very little attention has been given to the maternal immune system role in the elimination of infections. In preparation for implantation, the uterine ...
Persistent Identifiers
Subjects
free text keywords: Tolerância immunológica materno-fetal, Infecções virais e bacterianas na gravidez humana
Related Organizations
Funded by
FCT| SFRH/BD/33885/2009
Project
SFRH/BD/33885/2009
MODULATION OF NATURAL KILLER CELLS AND MACROPHAGES IN THE MATERNAL FETAL INTERFACE - CYTOTOXICITY AND CYTOKINE SECRETION
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/33885/2009
  • Funding stream: SFRH | Doutoramento
77 references, page 1 of 6

CHAPTER 3 - EXPRESSION OF KIR2DS1 BY DECIDUAL NK CELLS INCREASES THEIR ABILITY TO CONTROL PLACENTAL HCMV INFECTION ...............................................................................48 CHAPTER 4 - CONTROL OF BACTERIAL INFECTIONS BY DECIDUAL NATURAL KILLER CELL - SECRETED GRANULYSIN .............................................................................................................65 CHAPTER 5 - GENERAL DISCUSSION........................................................................................81 1. Goldsby, R. A., T. J. Kindt, B. A. Osborne, and J. Kuby. 2003. Immunology, 5th ed. (J. Noe, M. Ryan, J. Ciprioni, K. Mergen, G. Hadler, A. Kudlacik, and N. Villamora, eds). W.H. Freeman and Company, New York.

2. Medzhitov, R., and C. a Janeway. 2002. Decoding the patterns of self and nonself by the innate immune system. Science 296: 298-300. [OpenAIRE]

3. York, I. a, and K. L. Rock. 1996. Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 14: 369-396.

4. Chervin, A. S., J. D. Stone, P. D. Holler, A. Bai, J. Chen, H. N. Eisen, and D. M. Kranz. 2009. The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J. Immunol. 183: 1166-78.

5. Bogunia-Kubik, K., and M. Iwaszko. 2011. Clinical Significance of the HLA-E and CD94 / NKG2 Interaction. Arch. Immunol. Ther. Exp. 59: 353-367. [OpenAIRE]

6. Amiot, L., N. Vu, and M. Samson. 2014. Immunomodulatory Properties of HLA-G in Infectious Diseases. J. Immunol. Res. 2014: 298569. [OpenAIRE]

7. Petroff, M. G. 2005. Immune interactions at the maternal - fetal interface. J. Reprod. Immunol. 68: 1-13.

8. Roche, P. a., and K. Furuta. 2015. The ins and outs of MHC class II-mediated antigen processing and presentation. Nat. Rev. Immunol. 15: 203-216.

9. Abbey, J. L., and H. C. O'Neill. 2008. Expression of T-cell receptor genes during early Tcell development. Immunol. Cell Biol. 86: 166-174.

10. Starr, T. K., S. C. Jameson, and K. a Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21: 139-176.

11. Shah, D. K., and J. C. Zúñiga-Pflücker. 2014. An overview of the intrathymic intricacies of T cell development. J. Immunol. 192: 4017-23.

12. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8: 275-283. [OpenAIRE]

13. Toda, A., and C. a Piccirillo. 2006. Development and function of naturally occurring CD4+CD25+ regulatory T cells. J. Leukoc. Biol. 80: 458-70.

14. Chowdhury, D., and J. Lieberman. 2008. Death by a thousand cuts: granzyme pathways of programmed cell death. Annu. Rev. Immunol. 26: 389-420.

15. Thiery, J., D. Keefe, S. Boulant, E. Boucrot, M. Walch, D. Martinvalet, I. S. Goping, R. C. Bleackley, T. Kirchhausen, and J. Lieberman. 2011. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat. Immunol. 12: 770-7.

77 references, page 1 of 6
Abstract
Tese de doutoramento em Biociências, na área de especialização de Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra Human pregnancy is a challenge for the maternal immune system, which must maintain tolerance to a semi-foreign entity (the fetus) while keeping immunity against viral, bacterial and parasite infections. While the mechanisms involved in placental immune tolerance have been addressed for the last thirty years, very little attention has been given to the maternal immune system role in the elimination of infections. In preparation for implantation, the uterine ...
Persistent Identifiers
Subjects
free text keywords: Tolerância immunológica materno-fetal, Infecções virais e bacterianas na gravidez humana
Related Organizations
Funded by
FCT| SFRH/BD/33885/2009
Project
SFRH/BD/33885/2009
MODULATION OF NATURAL KILLER CELLS AND MACROPHAGES IN THE MATERNAL FETAL INTERFACE - CYTOTOXICITY AND CYTOKINE SECRETION
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/33885/2009
  • Funding stream: SFRH | Doutoramento
77 references, page 1 of 6

CHAPTER 3 - EXPRESSION OF KIR2DS1 BY DECIDUAL NK CELLS INCREASES THEIR ABILITY TO CONTROL PLACENTAL HCMV INFECTION ...............................................................................48 CHAPTER 4 - CONTROL OF BACTERIAL INFECTIONS BY DECIDUAL NATURAL KILLER CELL - SECRETED GRANULYSIN .............................................................................................................65 CHAPTER 5 - GENERAL DISCUSSION........................................................................................81 1. Goldsby, R. A., T. J. Kindt, B. A. Osborne, and J. Kuby. 2003. Immunology, 5th ed. (J. Noe, M. Ryan, J. Ciprioni, K. Mergen, G. Hadler, A. Kudlacik, and N. Villamora, eds). W.H. Freeman and Company, New York.

2. Medzhitov, R., and C. a Janeway. 2002. Decoding the patterns of self and nonself by the innate immune system. Science 296: 298-300. [OpenAIRE]

3. York, I. a, and K. L. Rock. 1996. Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 14: 369-396.

4. Chervin, A. S., J. D. Stone, P. D. Holler, A. Bai, J. Chen, H. N. Eisen, and D. M. Kranz. 2009. The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J. Immunol. 183: 1166-78.

5. Bogunia-Kubik, K., and M. Iwaszko. 2011. Clinical Significance of the HLA-E and CD94 / NKG2 Interaction. Arch. Immunol. Ther. Exp. 59: 353-367. [OpenAIRE]

6. Amiot, L., N. Vu, and M. Samson. 2014. Immunomodulatory Properties of HLA-G in Infectious Diseases. J. Immunol. Res. 2014: 298569. [OpenAIRE]

7. Petroff, M. G. 2005. Immune interactions at the maternal - fetal interface. J. Reprod. Immunol. 68: 1-13.

8. Roche, P. a., and K. Furuta. 2015. The ins and outs of MHC class II-mediated antigen processing and presentation. Nat. Rev. Immunol. 15: 203-216.

9. Abbey, J. L., and H. C. O'Neill. 2008. Expression of T-cell receptor genes during early Tcell development. Immunol. Cell Biol. 86: 166-174.

10. Starr, T. K., S. C. Jameson, and K. a Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21: 139-176.

11. Shah, D. K., and J. C. Zúñiga-Pflücker. 2014. An overview of the intrathymic intricacies of T cell development. J. Immunol. 192: 4017-23.

12. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8: 275-283. [OpenAIRE]

13. Toda, A., and C. a Piccirillo. 2006. Development and function of naturally occurring CD4+CD25+ regulatory T cells. J. Leukoc. Biol. 80: 458-70.

14. Chowdhury, D., and J. Lieberman. 2008. Death by a thousand cuts: granzyme pathways of programmed cell death. Annu. Rev. Immunol. 26: 389-420.

15. Thiery, J., D. Keefe, S. Boulant, E. Boucrot, M. Walch, D. Martinvalet, I. S. Goping, R. C. Bleackley, T. Kirchhausen, and J. Lieberman. 2011. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat. Immunol. 12: 770-7.

77 references, page 1 of 6
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