publication . Other literature type . Article . 2009

Surface characteristics, copper release, and toxicity of nano- and micrometer-sized copper and copper(II) oxide particles: a cross-disciplinary study.

Karine Elihn;
  • Published: 06 Feb 2009
  • Publisher: Wiley
  • Country: Poland
An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano- and micrometer-sized particles of oxidized metallic copper and copper(II) oxide in contact with cultivated lung cells, as well as copper release in relevant media. All particles, except micrometer-sized Cu, release more copper in serum-containing cell medium (supplemented Dulbecco's minimal essential medium) compared to identical exposures in phosphate-buffered saline. Sonication of particles for dispersion prior to exposure has a large effect on the initial copper release from Cu nanoparticles. A clear size-dependent effect is obs...
free text keywords: cytotoxicity, DNA damage, nanoparticles, particle characterization, Biotechnology, Engineering (miscellaneous), Biomaterials, Micrometer, law.invention, law, Nanoparticle, Nanotechnology, Copper(II) oxide, chemistry.chemical_compound, chemistry, Materials science, Metal, visual_art.visual_art_medium, visual_art, Cross disciplinary, Nano-, Copper, chemistry.chemical_element
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