Oxidative stress and DNA damage caused by the urban air pollutant 3-NBA and its isomer 2-NBA in human lung cells analyzed with three independent methods.

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Nagy, Eszter; Johansson, Clara; Zeisig, Magnus; Moller, Lennart;
  • Related identifiers: doi: 10.1016/j.jchromb.2005.03.014
  • Subject: Air pollutant | Benz(a)anthracenes | Toxicity | Humans | Lung | DNA damage | Oxidative stress | Comet assay | Chromatography, High Pressure Liquid

The air pollutant 3-nitrobenzanthrone (3-NBA), emitted in diesel exhaust, is a potent mutagen and genotoxin. 3-NBA can isomerise to 2-nitrobenzanthrone (2-NBA), which can become more than 70-fold higher in concentration in ambient air. In this study, three independent m... View more
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