publication . Other literature type . Article . 2006

Balkan endemic nephropathy: Role of ochratoxins A through biomarkers

Marcel Castegnaro; Delphine Canadas; Terry Vrabcheva; Theodora Petkova-Bocharova; Ivan Nicolaï Chernozemsky; Annie Pfohl-Leszkowicz;
Open Access
  • Published: 01 Jun 2006
  • Publisher: Wiley
Abstract
Biomarker: DNA adductsExposure/effect represented: ochratoxin A (OTA) / DNA damageStudy type: humans, Dark Agouti ratsStudy design: cross-sectional studyStudy size: 16 healthy volunteersAnalytical technique: OTA food intake, OTA blood concentration and urinary OTA excretion; DNA adducts in kidney of male and female rats using post labellingTissue/biological material/sample size: human blood and urine; Dark Agouti rat blood, urine and kidneyImpact on outcome (including dose-response): Average weekly intake of OTA varies from 1.9 to 206 ng/kg body weight, twice tolerable weekly intake recommended by JECFA. OTA blood concentrations are in the same range as previous...
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free text keywords: Génie chimique, Balkan endemic nephropathy, Blood, Food, Mycotoxins, Ochratoxin A, Adult, Animals, Balkan Nephropathy, Biological Markers, DNA Adducts, Diet, Female, Food Contamination, Humans, Kidney, Male, Ochratoxins, Pedigree, Rats, Sex Characteristics, Triticum, Urologic Neoplasms, Biotechnology, Food Science, medicine.anatomical_structure, medicine, Food contaminant, Urine, Biology, Ochratoxin, chemistry.chemical_compound, chemistry, Toxicology, Excretion, Physiology, Urinary system
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