publication . Article . 1998

Nitric oxide in the stress axis

Lopez-Figueroa, M.O.; Day, H.E.W.; Akil, H.; Watson, S.J.;
Open Access
  • Published: 01 Jan 1998
  • Publisher: Murcia : F. Hernández
  • Country: Spain
In recent years nitric oxide (NO) has emerged as a unique biological messenger. NO is a highly diffusible gas, synthesized from L-arginine by the enzyme nitric oxide synthase (NOS). Three unique subtypes of NOS have been described, each with a specific distribution profile in the brain and periphery. NOS subtype I is present, among other areas, in the hippocampus, hypothalamus, pituitary and adrenal gland. Together these structures form the limbichypothalamic- pituitary-adrenal (LHPA) or stress axis, activation of which is one of the defining features of a stress response. Evidence suggests that NO may modulate the release of the stress hormones ACTH and cortico...
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free text keywords: Hypothalamus, Pituitary gland, :6 - Ciencias aplicadas::61 - Medicina [CDU]
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