Altered patterns of RB expression define groups of soft tissue sarcoma patients with distinct biological and clinical behavior

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Polsky, D.; Mastorides, S.; Kim, D.; Dudas, M.; Leon, L.; Leung, D.; Woodruff, J.M.; Brennan, M.F.; Osman, I.; Cordon-Cardo, C.;
  • Publisher: Murcia : F. Hernández
  • Subject: Sarcoma | Retinoblastoma | :6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU]
    mesheuropmc: biological phenomena, cell phenomena, and immunity | neoplasms

Background: Function of the retinoblastoma tumor suppressor protein (pRB) may be compromised at a genetic level by gene loss or mutation or at a posttranslational level by hyperphosphorylation. In this study, we examined adult soft tissue sarcomas (ASTS)... View more
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