publication . Article . 2009

MUC-1-ESA+ progenitor cells in normal benign and malignant human breast epithelial cells

Lu, Xinquan; Li, Huixiang; Xu, Kejia; Nesland, Jahn M.; Suo, Zhenhe;
Open Access English
  • Published: 01 Jan 2009
  • Publisher: Murcia : F. Hernández
  • Country: Spain
Abstract
The existence of mammary epithelial stem/progenitor cells has been demonstrated in MUC-1-/ ESA+ subpopulations of breast epithelial cells. However, knowledge about the expression and localization in benign and malignant breast lesions is unknown. Using a double-staining immunohistochemistry method, we investigated MUC-1-/ESA+ cells in 10 normal breast tissues, 49 cases with fibrocystic disease, 40 fibroadenomas, 36 invasive ductal carcinomas and the breast cancer cell lines MCF-7 and MDA-MB-468. In normal breast tissues MUC-1-/ESA+ cells were mainly found in the suprabasal layer, but under the apical surface of the duct/alveolus. In the hyperplastic areas of fib...
Subjects
Medical Subject Headings: skin and connective tissue diseaseshemic and lymphatic diseases
free text keywords: Mammary gland, Immunohistochemistry, 616 - Patología. Medicina clínica. Oncología
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