publication . Article . 1993

Lymphocyte interactions with the extracellular matrix of malignant cells in vítro: A morphological and immunocytochemical study

Logothetou-Rella, H.;
Open Access English
  • Published: 01 Jan 1993
  • Publisher: Murcia : F. Hernández
  • Country: Spain
Abstract
The interactions of lymphocytes with the glycosaminoglycans-protease-membrane extracellular matrix, produced by mixed cell cultures of normal with malignant cell clones, were examined. Pre-activated and activated heterologous peripheral lymphocytes were used. Co-cultures of activated lymphocytes with al1 cell types used, formed identical cell nodules. Histology of cell nodules showed that activated lymphocytes were cytolytic to pure normal or malignant cell clones. On the contrary, lymphocytes in nodules with mixed cell clones (normal with malignant cell clones) or embryonic cells, underwent degeneration changing the fusiform type tumor nodule into the adenoid t...
Subjects
free text keywords: Lymphocytes, Extracellular matrix, :6 - Ciencias aplicadas::61 - Medicina [CDU]
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