publication . Conference object . 2012

Irreducible coupling between physical and biological phenomena: overview of on-line and off-line physical measurements during high cell density cultures of yarrowia lipolytica

Kraiem, Hazar; Manon, Yannick; Anne-Archard, Dominique; Fillaudeau, Luc;
Open Access English
  • Published: 01 Jan 2012
  • Country: France
During cell cultures in bioreactor, micro-organism physiology closely interacts with physico-chemical parameters (gas and feed flow rates, mixing, temperature, pH, pressure). The specificity of microbial bioreactions in relation with irreducible couplings between heat and mass transfers and fluid mechanics, led into complex (three phases medium) and dynamic (auto-biocatalytic reaction) systems. Our scientific approach aims to investigate, understand and control dynamic interactions between physical and biological systems at different scales (macro, micro and molecular) for molecules, strains and/or bioprocess innovation in a white biotechnology context. Cells (c...
free text keywords: Génie chimique, Génie des procédés, Mécanique des fluides, Broth, Cell culture, Fed-batch, On-line and off-line measurement, Physical and physicochemical properties, Rheometry, Escherichia coli, Yarrowia lipolytica
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