publication . Article . Other literature type . 2018

A genome-wide association study of corneal astigmatism: The CREAM Consortium

Shah, R. L.; Li, Q.; Zhao, W.; Tedja, M. S.; Tideman, J. W. L.; Khawaja, A. P.; Fan, Q.; Yazar, S.; Williams, K. M.; Verhoeven, V. J. M.; ...
Open Access English
  • Published: 01 Feb 2018 Journal: Molecular Vision, volume 24, pages 127-142 (eissn: 1090-0535, Copyright policy)
  • Publisher: Molecular Vision
Abstract
Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for corneal and refractive astigmatism and ...
Subjects
free text keywords: Research Article, 610 Medicine & health, 610 Medicine & health, geenit, markkerit, sarveiskalvo, silmät, silmätaudit, genes, genetic markers, corneal astigmatism
Funded by
NHMRC| Pathways to precision medicine in eye disease
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 1138585
  • Funding stream: Research Fellowships
,
AKA| CoE in Complex Disease Genetics
Project
  • Funder: Academy of Finland (AKA)
  • Project Code: 213506
,
AKA| Center of Excellence in Complex Disease Genetics
Project
  • Funder: Academy of Finland (AKA)
  • Project Code: 129680
,
NHMRC| Genome-wide association study (GWAS) for juvenile-onset myopia and its component measures to identify molecular pathways to prevent myopia
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 1021105
  • Funding stream: Project Grants
,
EC| MYOP-PATH
Project
MYOP-PATH
Towards solving myopia: from genes to pathways using an integrated approach
  • Funder: European Commission (EC)
  • Project Code: 648268
  • Funding stream: H2020 | ERC | ERC-COG
67 references, page 1 of 5

Read, SA, Collins, MJ, Carney, LG. A review of astigmatism and its possible genesis.. Clin Exp Optom. 2007; 90: 5-19 [OpenAIRE] [PubMed]

Kee, CS. Astigmatism and its role in emmetropization.. Exp Eye Res. 2013; 114: 89-95 [PubMed]

Mozayan, E, Lee, JK. Update on astigmatism management.. Curr Opin Ophthalmol. 2014; 25: 286-90 [OpenAIRE] [PubMed]

Somer, D, Budak, K, Demirci, S, Duman, S. Against-the-rule (ATR) astigmatism as a predicting factor for the outcome of amblyopia treatment.. Am J Ophthalmol. 2002; 133: 741-5 [OpenAIRE] [PubMed]

Dunne, MC, Elawad, ME, Barnes, DA. A study of the axis of orientation of residual astigmatism.. Acta Ophthalmol (Copenh). 1994; 72: 483-9 [PubMed]

Keller, PR, Collins, MJ, Carney, LG, Davis, BA, vanSaarloos, PP. The relation between corneal and total astigmatism.. Optom Vis Sci. 1996; 73: 86-91 [PubMed]

Chu, CH, Kee, CS. Effects of optically imposed astigmatism on early eye growth in chicks.. PLoS One. 2015; 10: e0117729 [OpenAIRE] [PubMed]

Gwiazda, J, Scheiman, M, Mohindra, I, Held, R. Astigmatism in children: changes in axis and amount from birth to six years.. Invest Ophthalmol Vis Sci. 1984; 25: 88-92 [PubMed]

Harvey, EM, Dobson, V, Miller, JM, Schwiegerling, J, Clifford-Donaldson, CE, Green, TK, Messer, DH. Prevalence of corneal astigmatism in Tohono O’odham Native American children 6 months to 8 years of age.. Invest Ophthalmol Vis Sci. 2011; 52: 4350-5 [OpenAIRE] [PubMed]

Huynh, SC, Kifley, A, Rose, KA, Morgan, IG, Mitchell, P. Astigmatism in 12-year-old Australian children: comparisons with a 6-year-old population.. Invest Ophthalmol Vis Sci. 2007; 48: 73-82 [PubMed]

Sanfilippo, PG, Hewitt, AW, Hammond, CJ, Mackey, DA. The heritability of ocular traits.. Surv Ophthalmol. 2010; 55: 561-83 [PubMed]

Parssinen, O, Kauppinen, M, Kaprio, J, Koskenvuo, M, Rantanen, T. Heritability of refractive astigmatism: a population-based twin study among 63- to 75-year-old female twins.. Invest Ophthalmol Vis Sci. 2013; 54: 6063-7 [OpenAIRE] [PubMed]

Clementi, M, Angi, M, Forabosco, P, Di Gianantonio, E, Tenconi, R. Inheritance of astigmatism: evidence for a major autosomal dominant locus.. Am J Hum Genet. 1998; 63: 825-30 [OpenAIRE] [PubMed]

Lopes, MC, Hysi, PG, Verhoeven, VJ, Macgregor, S, Hewitt, AW, Montgomery, GW, Cumberland, P, Vingerling, JR, Young, TL, van Duijn, CM, Oostra, B, Uitterlinden, AG, Rahi, JS, Mackey, DA, Klaver, CC, Andrew, T, Hammond, CJ. Identification of a candidate gene for astigmatism.. Invest Ophthalmol Vis Sci. 2013; 54: 1260-7 [OpenAIRE] [PubMed]

Han, S, Chen, P, Fan, Q, Khor, CC, Sim, X, Tay, WT, Ong, RT, Suo, C, Goh, LK, Lavanya, R, Zheng, Y, Wu, R, Seielstad, M, Vithana, E, Liu, J, Chia, KS, Lee, JJ, Tai, ES, Wong, TY, Aung, T, Teo, YY, Saw, SM. Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.. Hum Mol Genet. 2011; 20: 3693-8 [PubMed]

67 references, page 1 of 5
Related research
Abstract
Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for corneal and refractive astigmatism and ...
Subjects
free text keywords: Research Article, 610 Medicine & health, 610 Medicine & health, geenit, markkerit, sarveiskalvo, silmät, silmätaudit, genes, genetic markers, corneal astigmatism
Funded by
NHMRC| Pathways to precision medicine in eye disease
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 1138585
  • Funding stream: Research Fellowships
,
AKA| CoE in Complex Disease Genetics
Project
  • Funder: Academy of Finland (AKA)
  • Project Code: 213506
,
AKA| Center of Excellence in Complex Disease Genetics
Project
  • Funder: Academy of Finland (AKA)
  • Project Code: 129680
,
NHMRC| Genome-wide association study (GWAS) for juvenile-onset myopia and its component measures to identify molecular pathways to prevent myopia
Project
  • Funder: National Health and Medical Research Council (NHMRC) (NHMRC)
  • Project Code: 1021105
  • Funding stream: Project Grants
,
EC| MYOP-PATH
Project
MYOP-PATH
Towards solving myopia: from genes to pathways using an integrated approach
  • Funder: European Commission (EC)
  • Project Code: 648268
  • Funding stream: H2020 | ERC | ERC-COG
67 references, page 1 of 5

Read, SA, Collins, MJ, Carney, LG. A review of astigmatism and its possible genesis.. Clin Exp Optom. 2007; 90: 5-19 [OpenAIRE] [PubMed]

Kee, CS. Astigmatism and its role in emmetropization.. Exp Eye Res. 2013; 114: 89-95 [PubMed]

Mozayan, E, Lee, JK. Update on astigmatism management.. Curr Opin Ophthalmol. 2014; 25: 286-90 [OpenAIRE] [PubMed]

Somer, D, Budak, K, Demirci, S, Duman, S. Against-the-rule (ATR) astigmatism as a predicting factor for the outcome of amblyopia treatment.. Am J Ophthalmol. 2002; 133: 741-5 [OpenAIRE] [PubMed]

Dunne, MC, Elawad, ME, Barnes, DA. A study of the axis of orientation of residual astigmatism.. Acta Ophthalmol (Copenh). 1994; 72: 483-9 [PubMed]

Keller, PR, Collins, MJ, Carney, LG, Davis, BA, vanSaarloos, PP. The relation between corneal and total astigmatism.. Optom Vis Sci. 1996; 73: 86-91 [PubMed]

Chu, CH, Kee, CS. Effects of optically imposed astigmatism on early eye growth in chicks.. PLoS One. 2015; 10: e0117729 [OpenAIRE] [PubMed]

Gwiazda, J, Scheiman, M, Mohindra, I, Held, R. Astigmatism in children: changes in axis and amount from birth to six years.. Invest Ophthalmol Vis Sci. 1984; 25: 88-92 [PubMed]

Harvey, EM, Dobson, V, Miller, JM, Schwiegerling, J, Clifford-Donaldson, CE, Green, TK, Messer, DH. Prevalence of corneal astigmatism in Tohono O’odham Native American children 6 months to 8 years of age.. Invest Ophthalmol Vis Sci. 2011; 52: 4350-5 [OpenAIRE] [PubMed]

Huynh, SC, Kifley, A, Rose, KA, Morgan, IG, Mitchell, P. Astigmatism in 12-year-old Australian children: comparisons with a 6-year-old population.. Invest Ophthalmol Vis Sci. 2007; 48: 73-82 [PubMed]

Sanfilippo, PG, Hewitt, AW, Hammond, CJ, Mackey, DA. The heritability of ocular traits.. Surv Ophthalmol. 2010; 55: 561-83 [PubMed]

Parssinen, O, Kauppinen, M, Kaprio, J, Koskenvuo, M, Rantanen, T. Heritability of refractive astigmatism: a population-based twin study among 63- to 75-year-old female twins.. Invest Ophthalmol Vis Sci. 2013; 54: 6063-7 [OpenAIRE] [PubMed]

Clementi, M, Angi, M, Forabosco, P, Di Gianantonio, E, Tenconi, R. Inheritance of astigmatism: evidence for a major autosomal dominant locus.. Am J Hum Genet. 1998; 63: 825-30 [OpenAIRE] [PubMed]

Lopes, MC, Hysi, PG, Verhoeven, VJ, Macgregor, S, Hewitt, AW, Montgomery, GW, Cumberland, P, Vingerling, JR, Young, TL, van Duijn, CM, Oostra, B, Uitterlinden, AG, Rahi, JS, Mackey, DA, Klaver, CC, Andrew, T, Hammond, CJ. Identification of a candidate gene for astigmatism.. Invest Ophthalmol Vis Sci. 2013; 54: 1260-7 [OpenAIRE] [PubMed]

Han, S, Chen, P, Fan, Q, Khor, CC, Sim, X, Tay, WT, Ong, RT, Suo, C, Goh, LK, Lavanya, R, Zheng, Y, Wu, R, Seielstad, M, Vithana, E, Liu, J, Chia, KS, Lee, JJ, Tai, ES, Wong, TY, Aung, T, Teo, YY, Saw, SM. Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.. Hum Mol Genet. 2011; 20: 3693-8 [PubMed]

67 references, page 1 of 5
Related research
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