publication . Doctoral thesis . 2013

Anti-cancer chemotherapeutics in target therapy: from advanced preclinical studies on promising Au(III) peptidomimetics toward the design of new receptor-recognizable metal-based agents

Open Access
  • Published: 31 Jan 2013
  • Country: Italy
At present, though there is no clinically available antineoplastic drug that acts selectively on the tumor tissue, chemotherapy is still the main form of treatment for cancer. To date, platinum-based drugs, whose forerunner is cisplatin, are among the most employed chemotherapeutics in spite of their treatment-related toxicity. Starting from the chemical properties of platinum and the severe toxicological profile of the drug cisplatin, novel Au(III)-dithiocarbamato complexes have been recently designed and biologically studied, showing particularly promising antitumor activity (both in vitro and in vivo), lack of cross-resistance, and reduced toxic and nephrotox...
free text keywords: CHIM/03 Chimica generale e inorganica
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Doctoral thesis . 2013
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