publication . Article . Other literature type . 1972

A theory of biological pattern formation

Alfred Gierer; Hans Meinhardt;
Open Access English
  • Published: 01 Dec 1972
  • Country: Germany
Abstract
One of the elementary processes in morphogenesis is the formation of a spatial pattern of tissue structures, starting from almost homogeneous tissue. It will be shown that relatively simple molecular mechanisms based on auto- and cross catalysis can account for a primary pattern of morphogens to determine pattern formation of the tissue. The theory is based on short range activation, long range inhibition, and a distinction between activator and inhibitor concentrations on one hand, and the densities of their sources on the other. While source density is expected to change slowly, e.g. as an effect of cell differentiation, the concentration of activators and inh...
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Subjects
free text keywords: ddc:000, Pattern formation, Aperiodic graph, Periodic graph (geometry), Polarity (international relations), Lateral inhibition, Autocatalysis, Common spatial pattern, Morphogen, Biological system
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