Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice

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Crettaz, J. (Julien); Berraondo, P. (Pedro); Mauleon, I. (Itsaso); Ochoa, L. (Laura); Shankar, V. (Vijay); Barajas, M. (Miguel); Rooijen, N. (Nico) van; Kochanek, S. (Stefan); Qian, C. (Cheng); Prieto, J. (Jesús); Hernandez-Alcoceba, R. (Rubén); Gonzalez-Aseguinolaza, G. (Gloria);
  • Publisher: Wiley-Blackwell
  • Related identifiers: doi: 10.1002/hep.21292/abstract
  • Subject: Adenoviridae/genetics | Gene Therapy/methods | Genetic Vectors/administration & dosage | Liver/virology

Recombinant adenoviruses (Ad) are among the most extensively used vectors for liver gene transfer. One of the major limitations for the clinical application of these vectors is the inflammatory immune response associated with systemic administration of high dose of viru... View more
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