publication . Article . 2013

Ketoconazole modulates the infectivity of Ichthyophonus sp. (Mesomycetozoa) in vivo in experimentally injected European sea bass

F Hontoria; MA González; A Sitjà-Bobadilla; O Palenzuela; P Alvarez-Pellitero;
Open Access
  • Published: 01 Sep 2013 Journal: Diseases of Aquatic Organisms, volume 105, pages 225-235 (issn: 0177-5103, eissn: 1616-1580, Copyright policy)
  • Publisher: Inter-Research Science Center
  • Country: Spain
Abstract
In vitro studies have confirmed the inhibitory effect of the azol-derivative ketoconazole (KZ) on the growth of Ichthyophonus, an important pathogen causing epizootics in wild and cultured fish. We evaluated the effect of KZ in vivo in European sea bass Dicentrarchus labrax experimentally infected with the same Ichthyophonus isolate. Liposomes were used to vehiculate different doses of KZ to increase the effect on Ichthyophonus and lower the toxicity of the drug, and KZ toxicity was assessed in cultured sea bass juveniles. We also studied the effect of liposomevehiculated KZ included in medicated food on ichthyophoniasis. KZ causes clear toxic effects in D. labr...
Subjects
free text keywords: Aquatic Science, Ecology, Evolution, Behavior and Systematics, Spore, Toxicity, Ichthyophonus, biology.organism_classification, biology, Infectivity, Fishery, Ketoconazole, medicine.drug, medicine, Anatomy, Dicentrarchus, In vivo, Sea bass, Dicentrarchus labrax, Liposomes
Communities
Fisheries and Aquaculture Management
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publication . Article . 2013

Ketoconazole modulates the infectivity of Ichthyophonus sp. (Mesomycetozoa) in vivo in experimentally injected European sea bass

F Hontoria; MA González; A Sitjà-Bobadilla; O Palenzuela; P Alvarez-Pellitero;