Structure-function studies of the staphylococcal methicillin resistance antirepressor MecR2

Article English OPEN
Arede, Pedro; Botelho, Tiago O.; Guevara, Tibisay; Usón, Isabel; Oliveira, Duarte C.; Gomis-Rüth, F. Xavier; Gomis-Rüth, F. Xavier;
(2013)
  • Publisher: American Society for Biochemistry and Molecular Biology
  • Journal: Journal of Biological Chemistry (issn: 0021-9258, eissn: 1083-351X)
  • Related identifiers: handle: 10261/88252, doi: 10.1074/jbc.M112.448134
  • Subject: MRSA | Structural biology | Protein structure | Molecular biology | Microbiology | Antibiotic resistance

Methicillin resistance in Staphylococcus aureus is elicited by the MecI-MecR1-MecA axis encoded by the mec locus. Recently, MecR2 was also identified as the third regulator of mec through binding of the methicillin repressor, MecI. Here we show that plasmid-encoded full... View more
Share - Bookmark