publication . Article . 2010

Selective estrogen receptor modulators as brain therapeutic agents

Arévalo, María Ángeles; Santos-Galindo, María; Lagunas, Natalia; Azcoitia, I.; García-Segura, Luis M.;
Open Access
  • Published: 11 Nov 2010 Journal: Journal of Molecular Endocrinology, volume 46, pages R1-R9 (issn: 0952-5041, eissn: 1479-6813, Copyright policy)
  • Publisher: Bioscientifica
  • Country: Spain
Abstract
Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain. © 2011 Society for Endocrinology.
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
free text keywords: Molecular Biology, Endocrinology, Osteoporosis, medicine.disease, medicine, Breast cancer, Nervous system, medicine.anatomical_structure, Cognitive impairment, Neuroprotection, Inflammation, medicine.symptom, Selective estrogen receptor modulators, Internal medicine, medicine.medical_specialty, Biology
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