Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.

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Erny, Guillaume L. ; Cifuentes, Alejandro (2006)
  • Publisher: Elsevier
  • Related identifiers: handle: 10261/12149, doi: 10.1016/j.jpba.2005.10.044
  • Subject: Biological fluids | LC–MS | CE–MS | Enantiomers | Drugs | Capillary electrophoresis | Hyphenated techniques | Liquid chromatography | Metabolites | Sample preparation | CEC–MS

Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid s... View more
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