Morphological Differentiation Towards Neuronal Phenotype of SH-SY5Y Neuroblastoma Cells by Estradiol, Retinoic Acid and Cholesterol

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Teppola, Heidi; Sarkanen, Jertta-Riina; Jalonen, Tuula O.; Linne, Marja-Leena;
  • Publisher: Springer US
  • Journal: Neurochemical Research,volume 41,issue 4,pages731-747 (issn: 0364-3190, eissn: 1573-6903)
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  • Related identifiers: pmc: PMC4824837, doi: 10.1007/s11064-015-1743-6
  • Subject: Cellular and Molecular Neuroscience | fi=Biolääketieteet | en=Biomedicine| | Retinoic acid | Differentiation | SH-SY5Y | Biochemistry | Cholesterol | Brain-derived neurotrophic factor | Original Paper | fi=Lääketieteen tekniikka | en=Medical engineering| | Estradiol

Human SH-SY5Y neuroblastoma cells maintain their potential for differentiation and regression in culture conditions. The induction of differentiation could serve as a strategy to inhibit cell proliferation and tumor growth. Previous studies have shown that differentiati... View more
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