publication . Thesis . 2011

Transcutaneous delivery of T Cell-inducing viral vector Malaria vaccines by microneedle patches

Open Access English
  • Published: 01 Jan 2011
  • Country: United Kingdom
Abstract
<p>There is an urgent need for improvements to existing vaccine delivery technologies to run parallel with the development of new-generation vaccines. The burdens of needle-based immunisation strategies are exacerbated by poor resource provision in such areas as sub-Saharan Africa, where annual malaria mortality stands at 860,000. Needle-free delivery of vaccine to the skin holds promise for improved immunogenicity with lower doses of vaccine, in addition to significant logistical advantages. Various methods have been described for the transcutaneous delivery of vaccines, including the use of microneedles to overcome the outer <em>stratum corneum</em> of the ski...
Subjects
free text keywords: Life Sciences, Biology, Nano-biotechnology, Parasitology, Infectious diseases, Biology (medical sciences), Malaria, Immunology, Tropical medicine, Viruses, Vaccinology
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