publication . Other literature type . Article . 2018

Increased T cell trafficking as adjunct therapy for HIV-1.

Helen R. Fryer; Steven M. Wolinsky; Angela R. McLean;
  • Published: 01 Mar 2018
  • Publisher: Public Library of Science (PLoS)
  • Country: United Kingdom
Abstract
Author summary Despite the success of potent antiretroviral therapy in suppressing the amount of virus in peripheral blood for long periods of time, a reservoir of infectious virus persists in CD4 T cells, implying the need for long-term treatment. Strategies to control and ultimately eliminate the viral reservoir within specific tissue compartments will need to target virus that persists in both a long-lived reservoir of infectious virus in CD4 T cells as well as low-levels of viral replication that continues despite antiretroviral drug therapy. Using a mathematical model, we describe a hypothetical new therapeutic approach to eliminating HIV-1 persistence in t...
Subjects
free text keywords: Research Article, Biology and Life Sciences, Immunology, Vaccination and Immunization, Antiviral Therapy, Antiretroviral Therapy, Medicine and Health Sciences, Public and Occupational Health, Preventive Medicine, Cell Biology, Cellular Types, Animal Cells, Blood Cells, White Blood Cells, T Helper Cells, Immune Cells, Microbiology, Virology, Viral Replication, Medical Microbiology, Microbial Pathogens, Viral Pathogens, Immunodeficiency Viruses, HIV, HIV-1, Pathology and Laboratory Medicine, Pathogens, Organisms, Viruses, RNA viruses, Retroviruses, Lentivirus, T Cells, Pharmacology, Drugs, Antimicrobials, Antivirals, Antiretrovirals, Microbial Control, Viral Persistence and Latency, Anatomy, Lymphatic System, Lymphoid Tissue, Biology (General), QH301-705.5, Ecology, Modelling and Simulation, Computational Theory and Mathematics, Genetics, Ecology, Evolution, Behavior and Systematics, Molecular Biology, Cellular and Molecular Neuroscience, Bioinformatics, T cell, medicine.anatomical_structure, medicine, Disease reservoir, Virus latency, medicine.disease, Biology, Viral load, Adjunct
Related Organizations
Funded by
NIH| MULTICENTER AIDS COHORT STUDY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01AI035039-15
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| A Systems-level Approach to Studying HIV/AIDS Susceptibility and Substance Abuse
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01DA033773-01
  • Funding stream: NATIONAL INSTITUTE ON DRUG ABUSE
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