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Bachelor thesis . 2020

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Sagedasemate haiguste ning metaboliitide vahelised seosed Tartu Ülikooli Eesti Geenivaramu andmete põhjal

Name: Sagedasemate haiguste ning metaboliitide vahelised seosed Tartu Ülikooli Eesti Geenivaramu andmete põhjal
Creator: Hiie, Liis
Keywords: haiguste võrgustik, metaboloomika, comorbidity, logistic regression, komorbiidsus, logistiline regressioon, disease network, disease biomarker, metabolomics, haiguse biomarker

descriptionPublicationkeyboard_double_arrow_right Bachelor thesis 01 Jan 2020 Estonia Estonian

Authors: Hiie, Liis;

Sagedasemate haiguste ning metaboliitide vahelised seosed Tartu Ülikooli Eesti Geenivaramu andmete põhjal

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Abstract

Metabolism koondab kõiki organismis toimuvaid biokeemilisi protsesse, mille vahesaadustena ning tulemusel tekkivad metaboliidid. Metaboliitide abil on võimalik tuvastada metaboolseid muutuseid, mis on olulised erinevate haiguste tekkemehhanismide juures. Käesoleva bakalaureusetöö eesmärk on Tartu Ülikooli Eesti Geenivaramu andmete põhjal leida seoseid metaboliitide ning sagedasemate krooniliste haiguste tekke vahel. Olulised seosed leitakse logistiliste regressioonmudelite abil, võttes arvesse ka sugu, vanust, kehamassiindeksit, haridustaset ning suitsetamist. Leitud seostest tehakse ülevaade varasema kirjanduse põhjal. Lisaks koostatakse kaks haiguste võrgustikku: leitud metaboolsete biomarkerite ning haiguste komorbiidsuse skooride põhjal. Tehtud võrgustikke võrreldakse neis leitud haigustevaheliste seoste alusel.

Country

Estonia

Related Organizations

University of Tartu
Estonia

Keywords

haiguste võrgustik, metaboloomika, comorbidity, logistic regression, komorbiidsus, logistiline regressioon, disease network, disease biomarker, metabolomics, haiguse biomarker

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

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