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Bachelor thesis . 2022
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Rinnavähi riskitegurid ja nende mõju rinnavähi riskile TÜ Eesti geenivaramu andmete põhjal

Authors: Kuusk, Saskia;

Rinnavähi riskitegurid ja nende mõju rinnavähi riskile TÜ Eesti geenivaramu andmete põhjal

Abstract

Käesoleva bakalauseusetöö eesmärk on kirjeldada, kuidas sõltub rinnavähi esinemise risk geneetilistest teguritest. Tartu Ülikooli Eesti geenivaramu näitel uuritakse rinnavähi polügeense riskiskoori ja rinnavähi riski suurendavate harvade geenimutatsioonide mõju rinnavähi riskile. Selleks kasutatakse elukestuse iseloomustamiseks Kaplan-Meieri graafikuid ja Coxi võrdeliste riskide mudeleid. Töö esimeses peatükis tehakse ülevaade andmetest ja tutvustus Tartu Ülikooli Eesti geenivaramust. Teises peatükis antakse ülevaade töös kasutatavast statistilisest metoodikast. Kolmandas peatükis tuuakse välja geenivaramu andmetel tehtud analüüsi tulemused. Rinnavähi geneetilise riskiskoori ja harvade geenimutatsioonide olemasolu leiti analüüsi tulemusena tugeva mõjuga rinnavähi riskile. Geenimutatsiooniga naiste hulgas ei suudetud näidata, et riskiskooril oleks mõju rinnavähi riskile.

Country
Estonia
Related Organizations
Keywords

geenivaramu, biobank, breast cancer, elukestusanalüüs, polygenic risk score, rinnavähk, polügeenne riskiskoor, survival analysis

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
Cancer Research