Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.

Article, Doctoral thesis English OPEN
Østerholt, Helene C. D.; Dannevig, Ingrid; Wyckoff, Myra H.; Liao, Jie; Akgul, Yucel; Ramgopal, Mrithyunjay; Mija, Dan S.; Cheong, Naeun; Longoria, Christopher; Mahendroo, Mala; Nakstad, Britt; Saugstad, Ola D.; Savani, Rashmin C.;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 7, issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0038839, pmc: PMC3372475
  • Subject: Respiratory System | Animal Models | Research Article | Biology | Molecular Cell Biology | Immune Physiology | Immune Cells | Medicine | Critical Care and Emergency Medicine | Anatomy and Physiology | Q | Neonatology | R | Cytochemistry | Model Organisms | Biochemistry | Pediatrics | Science | Resuscitation | Cytokines | Extracellular Matrix

BACKGROUND: Newborn resuscitation with 100% oxygen is associated with oxidative-nitrative stresses and inflammation. The mechanisms are unclear. Hyaluronan (HA) is fragmented to low molecular weight (LMW) by oxidative-nitrative stresses and can promote inflammation. We ... View more
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