publication . Article . 2008

Poor outcomes of chronic active Epstein-Barr virus infection and hemophagocytic lymphohistiocytosis in non-Japanese adult patients

Gabe S. Sonke; Inge Ludwig; Hannah van Oosten; Joke W. Baars; Ellen Meijer; Arnon P. Kater; Daphne de Jong;
Open Access English
  • Published: 01 Jul 2008
  • Country: Netherlands
Abstract
textabstractChronic active Epstein-Barr virus infection manifests as a combination of persistent infectious mononucleosis-like symptoms and high viral load in apparently immunocompetent patients. It is closely related to Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. These 2 abnormal Epstein-Barr virus-associated diseases are seldom reported in individuals other than Japanese children and adolescents. We report a series of 2 adult non-Japanese patients with fatal chronic active Epstein-Barr virus and 1 adult non-Japanese patient with Epstein-Barr virus hemophagocytic lymphohistiocytosis and discuss its pathogenesis and treatment options.
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Subjects
Medical Subject Headings: hemic and lymphatic diseasesviruses
free text keywords: Microbiology (medical), Infectious Diseases, Viral load, Virus, Medicine, business.industry, business, Epstein–Barr virus infection, medicine.disease, Viral disease, Immunopathology, Pathogenesis, Immunology, Hemophagocytic lymphohistiocytosis, Chronic Active
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