Are Selective Serotonin Reuptake Inhibitors Safe for Drivers? What is the Evidence?

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Ravera, S.; Ramaekers, J.G.; Jong-van den Berg, L.T.W.; de Gier, J.J.;
  • Subject: CROSSOVER TRIAL | pharmacoepidemiologic studies | traffic accident | BEHAVIORAL TOXICITY | CRASH RISK | DRIVING PERFORMANCE | TERM TREATMENT | automobile driving | adverse effect | experimental research | selective serotonin reuptake inhibitors | DEPRESSED-PATIENTS | ROAD-TRAFFIC ACCIDENTS | MEDICINAL DRUGS | HEALTHY-SUBJECTS | TRICYCLIC ANTIDEPRESSANTS

Background: Selective serotonin reuptake inhibitors (SSRIs) are widely used medications to treat several psychiatric diseases and, above all, depression. They seem to be as effective as older antidepressants but have a different adverse effect profile. Despite their fav... View more
  • References (67)
    67 references, page 1 of 7

    1. Verster JC, Ramaekers JG. Antidepressants and traffic safety. In: Verster JC, Pandi-Perumal SR, Ramaekers JG, de Gier JJ, eds. Drugs, Driving and Traffic Safety. Basel-BostonBerlin, Switzerland: Birkaeuser Verlag AG; 2009:307-313.

    2. Katzung BG. Basic and Clinical Pharmacology. 8th ed. New York, NY: Lange Medical Books/McGraw-Hill; 2001.

    3. Trindade E, Menon D, Topfer LA, Coloma C. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. CMAJ. 1998;159:1245-1252.

    4. Wadsworth EJ, Moss SC, Simpson SA, Smith AP. Psychotropic medication use and accidents, injuries and cognitive failures. Hum Psychopharmacol. 2005;20:391- 400.

    5. Walinder J. Comparative efficacy and safety of selective serotonin reuptake inhibitors in the short- and mediumterm treatment of major depressive disorders. Nord J Psychiatry. 1996;50:55-59.

    6. Westenberg HG, Sandner C. Tolerability and safety of fluvoxamine and other antidepressants. Int J Clin Pract. 2006;60:482- 491.

    7. Sansone RA, Sansone LA. Driving on antidepressants: cruising for a crash? Psychiatry. 2009;6:13-16.

    8. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). An inventory of literature on the relation between drug use, impaired driving and traffic accidents (CT.97.EP.14). http://www.drugsandalcohol. ie/5308/1/1366-1591.pdf. Accessed September 15, 2011.

    9. Ramaekers JG. Pitfalls in estimating drug-related crash risk. Trends Pharmacol Sci. 2003;24:114 -115.

    10. Raes E, van den Neste T, Verstraete AG. Drug use, impaired driving and traffic accidents. http://www.emcdda.europa. eu/publications/insights/driving. Accessed September 15, 2011.

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