publication . Article . Other literature type . 2015

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Michailidou, K.; Beesley, J.; Lindstrom, S.; Canisius, S.; Dennis, J.; Lush, M.J.; Maranian, M.J.; Bolla, M.K.; Wang, Q.; Shah, M.; ...
Open Access English
  • Published: 09 Mar 2015 Journal: Nature genetics, volume 47, issue 4, pages 373-380 (issn: 1061-4036, eissn: 1546-1718, Copyright policy)
Abstract
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with ...
Subjects
free text keywords: Article, CONFER SUSCEPTIBILITY, GENOTYPE IMPUTATION, COMMON VARIANTS, OVARIAN-CANCER, RISK, ESTROGEN, CHEK2-ASTERISK-1100DELC, METAANALYSIS, ALLELES, BRCA1, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
EC| COGS
Project
COGS
Collaborative Oncological Gene-environment Study
  • Funder: European Commission (EC)
  • Project Code: 223175
  • Funding stream: FP7 | SP1 | HEALTH
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
NIH| Discovery Expansion and Replication
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U19CA148065-04
  • Funding stream: NATIONAL CANCER INSTITUTE
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