publication . Article . Other literature type . 2016

Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus.

Junge, Sibylle; Görlich, Dennis; den Reijer, Martijn; Wiedemann, Bärbel; Tümmler, Burkhard; Ellemunter, Helmut; Dübbers, Angelika; Küster, Peter; Ballmann, Manfred; Koerner-Rettberg, Cordula; ...
Open Access
  • Published: 18 Nov 2016 Journal: PLOS ONE, volume 11, page e0166220 (eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
  • Country: Netherlands
Abstract
Background Staphylococcus aureus is an important pathogen in cystic fibrosis (CF). However, it is not clear which factors are associated with worse lung function in patients with persistent S. aureus airway cultures. Our main hypothesis was that patients with high S. aureus density in their respiratory specimens would more likely experience worsening of their lung disease than patients with low bacterial loads. Methods Therefore, we conducted an observational prospective longitudinal multi-center study and assessed the association between lung function and S. aureus bacterial density in respiratory samples, co-infection with other CF-pathogens, nasal S. aureus c...
Subjects
free text keywords: Gastroenterology, medicine.medical_specialty, medicine, Cystic fibrosis, medicine.disease, Lung, medicine.anatomical_structure, Stenotrophomonas maltophilia, biology.organism_classification, biology, Sputum, medicine.symptom, Sulfamethoxazole, medicine.drug, Trimethoprim, business.industry, business, Pseudomonas aeruginosa, medicine.disease_cause, Microbiology, Staphylococcus aureus, Internal medicine, Research Article, Biology and Life Sciences, Organisms, Bacteria, Staphylococcus, Medical Microbiology, Microbial Pathogens, Bacterial Pathogens, Medicine and Health Sciences, Pathology and Laboratory Medicine, Pathogens, Anatomy, Neck, Throat, Body Fluids, Mucus, Physiology, Fungi, Molds (Fungi), Aspergillus, Aspergillus Fumigatus, Fungal Pathogens, Mycology, Pseudomonas, Virology, Co-Infections, Pharmacology, Drugs, Antimicrobials, Antibiotics, Microbial Control
Related Organizations
41 references, page 1 of 3

1. O'Sullivan BP, Freedman SD (2009) Cystic fibrosis. Lancet 373: 1891±1904. doi: 10.1016/S0140-6736 (09)60327-5 PMID: 19403164

2. Zolin A, McKone EF, van Rens J, Fox A, Iansa P (2016) ECFSPR Annual Report 2013.

3. Stone A, Saiman L (2007) Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis. Curr Opin Pulm Med 13: 515±521. doi: 10.1097/MCP.0b013e3282efbbac PMID: 17901758 [OpenAIRE]

4. 2015 Cystic Fibrosis Foundation (2015) 2014 Annual Data Report. Cystic Fibrosis Foundation Patient Registry, Bethesda, Maryland;.

5. Gangell C, Gard S, Douglas T, Park J, de KN, Keil T, Brennan S, Ranganathan S, Robins-Browne R, Sly PD (2011) Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis. Clin Infect Dis 53: 425±432. doi: 10.1093/cid/cir399 PMID: 21844026

6. Sagel SD, Gibson RL, Emerson J, McNamara S, Burns JL, Wagener JS, Ramsey BW (2009) Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis. J Pediatr 154: 183±188. doi: 10.1016/j.jpeds.2008.08.001 PMID: 18822427 [OpenAIRE]

7. Smyth AR, Walters S (2012) Prophylactic anti-staphylococcal antibiotics for cystic fibrosis. Cochrane Database Syst Rev 12: CD001912. doi: 10.1002/14651858.CD001912.pub2 PMID: 23235585

8. Ramsey KA, Ranganathan S, Park J, Skoric B, Adams AM, Simpson SJ, Robins-Browne RM, Franklin PJ, de Klerk NH, Sly PD, Stick SM, Hall GL (2014) Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis. Am J Respir Crit Care Med 190: 1111±1116. doi: 10.1164/ rccm.201407-1277OC PMID: 25321321

9. Wong JK, Ranganathan SC, Hart E (2013) Staphylococcus aureus in early cystic fibrosis lung disease. Pediatr Pulmonol 48: 1151±1159. doi: 10.1002/ppul.22863 PMID: 23970476

10. Wertheim HF, Melles DC, Vos MC, van LW, van BA, Verbrugh HA, Nouwen JL (2005) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5: 751±762. doi: 10.1016/S1473-3099 (05)70295-4 PMID: 16310147 [OpenAIRE]

11. Ridder-Schaphorn S, Ratjen F, Dubbers A, Haberle J, Falk S, Kuster P, Schuster A, Mellies U, Lowe B, Reintjes R, Peters G, Kahl BC (2007) Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients. J Clin Microbiol 45: 2979±2984. doi: 10.1128/ JCM.00855-07 PMID: 17652474 [OpenAIRE]

12. Goerke C, Kraning K, Stern M, Doring G, Botzenhart K, Wolz C (2000) Molecular epidemiology of community-acquired Staphylococcus aureus in families with and without cystic fibrosis patients. J Infect Dis 181: 984±989. doi: 10.1086/315331 PMID: 10720521

13. Wertheim HF, Vos MC, Ott A, van BA, Voss A, Kluytmans JA, van Keulen PH, Vandenbroucke-Grauls CM, Meester MH, Verbrugh HA (2004) Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet 364: 703±705. doi: 10.1016/S0140-6736(04) 16897-9 PMID: 15325835 [OpenAIRE]

14. Horsley AR, Davies JC, Gray RD, Macleod KA, Donovan J, Aziz ZA, Bell NJ, Rainer M, Mt-Isa S, Voase N, Dewar MH, Saunders C, Gibson JS, Parra-Leiton J, Larsen MD, Jeswiet S, Soussi S, Bakar Y, Meister MG, Tyler P, Doherty A, Hansell DM, Ashby D, Hyde SC, Gill DR, Greening AP, Porteous DJ, Innes JA, Boyd AC, Griesenbach U, Cunningham S, Alton EW (2013) Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. Thorax 68: 532±539. doi: 10.1136/thoraxjnl-2012-202538 PMID: 23396354

15. Mensa J, Trilla A (2006) Should patients with acute exacerbation of chronic bronchitis be treated with antibiotics? Advantages of the use of fluoroquinolones. Clin Microbiol Infect 12 Suppl 3: 42±54.

41 references, page 1 of 3
Abstract
Background Staphylococcus aureus is an important pathogen in cystic fibrosis (CF). However, it is not clear which factors are associated with worse lung function in patients with persistent S. aureus airway cultures. Our main hypothesis was that patients with high S. aureus density in their respiratory specimens would more likely experience worsening of their lung disease than patients with low bacterial loads. Methods Therefore, we conducted an observational prospective longitudinal multi-center study and assessed the association between lung function and S. aureus bacterial density in respiratory samples, co-infection with other CF-pathogens, nasal S. aureus c...
Subjects
free text keywords: Gastroenterology, medicine.medical_specialty, medicine, Cystic fibrosis, medicine.disease, Lung, medicine.anatomical_structure, Stenotrophomonas maltophilia, biology.organism_classification, biology, Sputum, medicine.symptom, Sulfamethoxazole, medicine.drug, Trimethoprim, business.industry, business, Pseudomonas aeruginosa, medicine.disease_cause, Microbiology, Staphylococcus aureus, Internal medicine, Research Article, Biology and Life Sciences, Organisms, Bacteria, Staphylococcus, Medical Microbiology, Microbial Pathogens, Bacterial Pathogens, Medicine and Health Sciences, Pathology and Laboratory Medicine, Pathogens, Anatomy, Neck, Throat, Body Fluids, Mucus, Physiology, Fungi, Molds (Fungi), Aspergillus, Aspergillus Fumigatus, Fungal Pathogens, Mycology, Pseudomonas, Virology, Co-Infections, Pharmacology, Drugs, Antimicrobials, Antibiotics, Microbial Control
Related Organizations
41 references, page 1 of 3

1. O'Sullivan BP, Freedman SD (2009) Cystic fibrosis. Lancet 373: 1891±1904. doi: 10.1016/S0140-6736 (09)60327-5 PMID: 19403164

2. Zolin A, McKone EF, van Rens J, Fox A, Iansa P (2016) ECFSPR Annual Report 2013.

3. Stone A, Saiman L (2007) Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis. Curr Opin Pulm Med 13: 515±521. doi: 10.1097/MCP.0b013e3282efbbac PMID: 17901758 [OpenAIRE]

4. 2015 Cystic Fibrosis Foundation (2015) 2014 Annual Data Report. Cystic Fibrosis Foundation Patient Registry, Bethesda, Maryland;.

5. Gangell C, Gard S, Douglas T, Park J, de KN, Keil T, Brennan S, Ranganathan S, Robins-Browne R, Sly PD (2011) Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis. Clin Infect Dis 53: 425±432. doi: 10.1093/cid/cir399 PMID: 21844026

6. Sagel SD, Gibson RL, Emerson J, McNamara S, Burns JL, Wagener JS, Ramsey BW (2009) Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis. J Pediatr 154: 183±188. doi: 10.1016/j.jpeds.2008.08.001 PMID: 18822427 [OpenAIRE]

7. Smyth AR, Walters S (2012) Prophylactic anti-staphylococcal antibiotics for cystic fibrosis. Cochrane Database Syst Rev 12: CD001912. doi: 10.1002/14651858.CD001912.pub2 PMID: 23235585

8. Ramsey KA, Ranganathan S, Park J, Skoric B, Adams AM, Simpson SJ, Robins-Browne RM, Franklin PJ, de Klerk NH, Sly PD, Stick SM, Hall GL (2014) Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis. Am J Respir Crit Care Med 190: 1111±1116. doi: 10.1164/ rccm.201407-1277OC PMID: 25321321

9. Wong JK, Ranganathan SC, Hart E (2013) Staphylococcus aureus in early cystic fibrosis lung disease. Pediatr Pulmonol 48: 1151±1159. doi: 10.1002/ppul.22863 PMID: 23970476

10. Wertheim HF, Melles DC, Vos MC, van LW, van BA, Verbrugh HA, Nouwen JL (2005) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5: 751±762. doi: 10.1016/S1473-3099 (05)70295-4 PMID: 16310147 [OpenAIRE]

11. Ridder-Schaphorn S, Ratjen F, Dubbers A, Haberle J, Falk S, Kuster P, Schuster A, Mellies U, Lowe B, Reintjes R, Peters G, Kahl BC (2007) Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients. J Clin Microbiol 45: 2979±2984. doi: 10.1128/ JCM.00855-07 PMID: 17652474 [OpenAIRE]

12. Goerke C, Kraning K, Stern M, Doring G, Botzenhart K, Wolz C (2000) Molecular epidemiology of community-acquired Staphylococcus aureus in families with and without cystic fibrosis patients. J Infect Dis 181: 984±989. doi: 10.1086/315331 PMID: 10720521

13. Wertheim HF, Vos MC, Ott A, van BA, Voss A, Kluytmans JA, van Keulen PH, Vandenbroucke-Grauls CM, Meester MH, Verbrugh HA (2004) Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet 364: 703±705. doi: 10.1016/S0140-6736(04) 16897-9 PMID: 15325835 [OpenAIRE]

14. Horsley AR, Davies JC, Gray RD, Macleod KA, Donovan J, Aziz ZA, Bell NJ, Rainer M, Mt-Isa S, Voase N, Dewar MH, Saunders C, Gibson JS, Parra-Leiton J, Larsen MD, Jeswiet S, Soussi S, Bakar Y, Meister MG, Tyler P, Doherty A, Hansell DM, Ashby D, Hyde SC, Gill DR, Greening AP, Porteous DJ, Innes JA, Boyd AC, Griesenbach U, Cunningham S, Alton EW (2013) Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. Thorax 68: 532±539. doi: 10.1136/thoraxjnl-2012-202538 PMID: 23396354

15. Mensa J, Trilla A (2006) Should patients with acute exacerbation of chronic bronchitis be treated with antibiotics? Advantages of the use of fluoroquinolones. Clin Microbiol Infect 12 Suppl 3: 42±54.

41 references, page 1 of 3
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publication . Article . Other literature type . 2016

Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus.

Junge, Sibylle; Görlich, Dennis; den Reijer, Martijn; Wiedemann, Bärbel; Tümmler, Burkhard; Ellemunter, Helmut; Dübbers, Angelika; Küster, Peter; Ballmann, Manfred; Koerner-Rettberg, Cordula; ...