DNA-Dependent Protein Kinase in Non-Homologous End-Joining: Guarding Strategic Positions
Publisher: Erasmus University Rotterdam
markdownabstract__Abstract__ Careful maintenance of genetic information throughout generations is of vital importance to all living creatures. A battery of both endogenous and exogenous factors continuously threatens genetic integrity by altering the DNA chemistry. As a...
G.C. Smith and S.P. Jackson, The DNA-dependent protein kinase. Genes Dev, 13 (1999) 916-34.
Y. Ma, U. Pannicke, K. Schwarz and M.R. Lieber, Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell, 108 (2002) 781-94.
Q. Ding, Y.V. Reddy, W. Wang, T. Woods, P. Douglas, D.A. Ramsden, S.P. Lees-Miller and K. Meek, Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Bioi, 23 (2003) 5836-48.
Chen, Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev, 16 (2002) 2333-8.
S. Soubeyrand, L. Pope, B. Pakuts and R.J. Hache, Threonines 2638/2647 in DNAPK are essential for cellular resistance to ionizing radiation. Cancer Res, 63 (2003) 1198-201.
L.G. DeFazio, R.M. Stansel, J.D. Griffith and G. Chu, Synapsis of DNA ends by DNAdependent protein kinase. Embo J, 21 (2002) 3192-200.
Embo J, 16 (1997) 5098-112.
R.B. Cary, S.R. Peterson, J. Wang, D.G. Bear, E.M. Bradbury and D.J. Chen, DNA looping by Ku and the DNA-dependent protein kinase. Proc Nat! Acad Sci U SA, 94 (1997) 4267-72.
L. Chen, K. Trujillo, P. Sung and A.E. Tomkinson, Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. J Bioi Chern, 275 (2000) 26196-205.
H.L. Hsu, S.M. Yannone and D.J. Chen, Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Arnst), 1 (2002) 225-35.