publication . Doctoral thesis . 1985

DNA synthesis in ataxia telangiectasia

Jaspers, Nicolaas;
Open Access English
  • Published: 20 Nov 1985
  • Publisher: Erasmus University Rotterdam
  • Country: Netherlands
Abstract
textabstractAfter the discovery that cultured cells from AT patients are hypersensitive to ionizing radiation the suggestion was made that AT-could be the 1 X-ray-analogue 1 of xeroderma pigmentosum. The latter syndrome (XP) is characterized by hypersensitivity to short-wave UV-radiation, caused by a reduced ability to properly remove UV-induced DNA damage. The evidence for a DNA repair defect in AT cells is not as strong as in the case of XP (see section 2.2.5 of this thesis). Different XP patients vary in their clinical and cellular UV-sensitivity, and this variability roughly correlates with the capacity to repair the UV damage in the DNA. in AT apparent diff...
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free text keywords: Cellular hypersensitivity, DNA, UV-radiation, biosynthesis, carcinogens, radiohypersensitivity, teleangiectasia
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Doctoral thesis . 1985
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