publication . Article . 1996

Potency of veterinary rabies vaccines in The Netherlands: A case for continued vigilance.

Rooijakkers, E.J.M.; Nieuwenhuijs, J.H.M.; Vermeulen, A.A.; Osterhaus, Albert; Steenis, Bert;
Open Access
  • Published: 01 Jan 1996 Journal: Veterinary Quarterly, volume 18, pages 146-150 (issn: 0165-2176, eissn: 1875-5941, Copyright policy)
  • Publisher: Informa UK Limited
  • Country: Netherlands
Abstract
textabstractCommercial rabies vaccines, used by veterinarians in the Netherlands, were collected for testing in the mouse potency test. Of the six vaccines tested, two were clearly below the minimal requirements for potency of 1.0 IU. Of these six vaccines the rabies virus glycoprotein (GP) and nucleoprotein (NP) contents were determined in an antigen competition ELISA. The GP content proved to correlate well with the potency found in the mouse potency test (r = 0.95, p < 0.01), whereas no such correlation was found for the NP content (r approximately 0, p > 0.05). After the manufacturers were told about the results, one of the two vaccines that did not comply w...
Subjects
free text keywords: General Veterinary, Biology, Veterinary medicine, Rabies virus, medicine.disease_cause, medicine, Virology, In vivo, Immunology, Rabies, medicine.disease, Antigen competition, Potency, Nucleoprotein, 0 (Glycoproteins), 0 (Nucleoproteins), 0 (Rabies Vaccines), Animal Diseases/epidemiology/immunology/*prevention & control, Animals, Chiroptera/virology, Comparative Study, Dogs, Enzyme-Linked Immunosorbent Assay/veterinary, Glycoproteins/analysis, Mice/immunology, Netherlands/epidemiology, Nucleoproteins/analysis, Rabies Vaccines/analysis/immunology/*standards, Rabies virus/immunology, Rabies/epidemiology/prevention & control/*veterinary
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publication . Article . 1996

Potency of veterinary rabies vaccines in The Netherlands: A case for continued vigilance.

Rooijakkers, E.J.M.; Nieuwenhuijs, J.H.M.; Vermeulen, A.A.; Osterhaus, Albert; Steenis, Bert;