publication . Article . 2008

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller.

Gerrit van Straten; Zita Soons;
Open Access
  • Published: 31 Jul 2008 Journal: Bioprocess and Biosystems Engineering, volume 32, pages 289-299 (issn: 1615-7591, eissn: 1615-7605, Copyright policy)
  • Publisher: Springer Nature
  • Country: Netherlands
Abstract This study considers two aspects of the implementation of a biomass growth observer and specific growth rate controller in scale-up from small- to pilot-scale bioreactors towards a feasible bulk production process for whole-cell vaccine against whooping cough. The first is the calculation of the oxygen uptake rate, the starting point for online monitoring and control of biomass growth, taking into account the dynamics in the gas-phase. Mixing effects and delays are caused by amongst others the headspace and tubing to the analyzer. These gas phase dynamics are modelled using knowledge of the system in order to reconstruct oxygen consumption. The second a...
free text keywords: Biotechnology, Bioengineering, General Medicine, fed-batch cultivation, fermentation processes, bordetella-pertussis, adaptive-control, online, design, state
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