Pseudomonas syringae evades host Immunity by degrading flagellin monomers with alkaline protease AprA

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Pel, M.J.C.; Van Dijken, A.J.H.; Bardoel, B.W.; Seidl, M.F; Van der Ent, S.; Van Strijp, J.A.G.;
(2014)
  • Subject: Pseudomonas, host immune evasion, plant immunity, flagellin, alkaline protease
    mesheuropmc: fungi

Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread a... View more
  • References (60)
    60 references, page 1 of 6

    Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.

    Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W. L., GómezGómez, L., Boller, T., Ausubel, F. M., and Sheen, J. 2002. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature 415:977-983.

    Bardoel, B. W., and Van Strijp, J. A. G. 2011. Molecular battle between host and bacterium: Recognition in innate immunity. J. Mol. Recognit. 24:1077-1086.

    Bardoel, B. W., Van der Ent, S., Pel, M. J. C., Tommassen, J., Pieterse, C. M. J., Van Kessel, K. P. M., and Van Strijp, J. A. G. 2011. Pseudomonas evades immune recognition of flagellin in both mammals and plants. PLoS Pathog. 7:e1002206.

    Bardoel, B. W., Van Kessel, K. P. M., Van Strijp, J. A. G., and Milder, F. J. 2012. Inhibition of Pseudomonas aeruginosa virulence: Characterization of the AprA-AprI interface and species selectivity. J. Mol. Biol. 415:573-583.

    Bethesda Research Laboratories. 1986. BRL pUC host: E. coli competent cells. Focus 8:9.

    Boller, T., and Felix, G. 2009. A renaissance of elicitors: Perception of microbe-associated molecular patterns and danger signals by patternrecognition receptors. Annu. Rev. Plant Biol. 60:379-406.

    Boller, T., and He, S. Y. 2009. Innate immunity in plants: An arms race between pattern recognition receptors in plants and effectors in microbial pathogens. Science 324:742-744.

    Bolton, M. D., Van Esse, H. P., Vossen, J. H., De Jonge, R., Stergiopoulos, I., Stulemeijer, I. J. E., Van den Berg, G. C. M., Borras-Hidalgo, O., Dekker, H. L., De Koster, C. G., de Wit, P. J., Joosten, M. H., and Thomma, B. P. 2008. The novel Cladosporium fulvum lysin motif effector Ecp6 is a virulence factor with orthologues in other fungal species. Mol. Microbiol. 69:119-136.

    Boyer, H. M., and Roulland-Dussoix, D. 1969. A complementation analysis of the restriction and modification of DNA in Escherichia coli. J. Mol. Biol. 41:459-472.

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