publication . Article . Other literature type . 2017

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

Joanne M. Donkers; Benno Zehnder; Gerard J. P. van Westen; Mark J. Kwakkenbos; Adriaan P. IJzerman; Ronald P. J. Oude Elferink; Ulrich Beuers; Stephan Urban; Stan F. J. van de Graaf;
Open Access
  • Published: 10 Nov 2017
  • Country: Netherlands
Abstract
The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) is the main hepatic transporter of conjugated bile acids, and the entry receptor for hepatitis B virus (HBV) and hepatitis delta virus (HDV). Myrcludex B, a synthetic peptide mimicking the NTCP-binding domain of HBV, effectively blocks HBV and HDV infection. In addition, Myrcludex B inhibits NTCP-mediated bile acid uptake, suggesting that also other NTCP inhibitors could potentially be a novel treatment of HBV/HDV infection. This study aims to identify clinically-applied compounds intervening with NTCP-mediated bile acid transport and HBV/HDV infection. 1280 FDA/EMA-approved drugs were screened ...
Subjects
Medical Subject Headings: digestive systemvirus diseasesviruses
free text keywords: Medicine, R, Science, Q, Article, Multidisciplinary
Funded by
EC| PROLONGBILESIGNALING
Project
PROLONGBILESIGNALING
Improving Metabolism via Prolonged Bile Acid Signalling targeting hepatic bile acid uptake to fight metabolic diseases
  • Funder: European Commission (EC)
  • Project Code: 337479
  • Funding stream: FP7 | SP2 | ERC
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