publication . Article . 2008

Mortality and preoperative cardiac function in vascular amputees: an N-terminal pro-brain natriuretic peptide (NT-proBNP) pilot study

Dirk Jan van Veldhuisen; Frits A.J. Muskiet; Marcel Riemersma; Jan H. B. Geertzen; Pieter U. Dijkstra; Jan A.M.M. van den Dungen;
Open Access English
  • Published: 01 Jan 2008
Abstract
Objective: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality. Design: Prospective pilot study.Subjects and methods: In 19 patients planned for a lower limb amputation for non-reconstructable peripheral arterial disease NT-proBNP was measured the day before amputation.Results: Four amputees died within 30 days after the amputation. In 17 of 19 patients NT-proBNP values were found more than 2 standard deviations above the age corrected reference value. Pre-amputation NT-proBNP levels did not...
Subjects
Medical Subject Headings: cardiovascular diseaseshormones, hormone substitutes, and hormone antagonists
free text keywords: Physical Therapy, Sports Therapy and Rehabilitation, Rehabilitation, N-terminal pro-Brain Natriuretic Peptide, Natriuretic peptide, medicine.drug_class, medicine, Amputation, medicine.medical_treatment, Lower limb amputation, Ventricular function, Cardiology, medicine.medical_specialty, business.industry, business, Peripheral, Surgery, Postoperative mortality, Cardiac function curve, Internal medicine
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1 Cruz CP, Eidt JF, Capps C, Kirtley L, Moursi MM. Major lower extremity amputations at a Veterans Affairs hospital. Am J Surg 2003; 186: 449-54. [OpenAIRE]

2 Aulivola B, Hile CN, Hamdan AD et al. Major lower extremity amputation - outcome of a modern series. Arch Surg 2004; 139: 395-99.

3 Jaegers SMHJ, Vos LDW, Rispens P, Hof AL. The relationship between comfortable and most metabolically efficient walking speed in persons with unilateral above-knee amputation. Arch Phys Med Rehabil 1993; 74: 521-25.

4 Gailey RS, Wenger MA, Raya M et al. Energyexpenditure of trans-tibial amputees during ambulation at self-selected pace. Prosthet Orthot Int 1994; 18: 84-91.

6 7 8 Czerniecki JM. Rehabilitation in limb deficiency.1.

Gait and motion analysis. Arch Phys Med Rehabil 1996; 77: S3-S8.

Biochemical detection of left-ventricular systolic dysfunction. Lancet 1998; 351: 9-13.

Increased brain and atrial natriuretic peptides in patients with chronic right ventricular pressure overload: correlation between plasma neurohormones and right ventricular dysfunction. Heart 2001; 86: 27-30.

Fisher C, Berry C, Blue L, Morton JJ, Hillier C, McMurray JJ. N terminal B-type natriuretic peptide, but not the FP437 putative cardiac hormone relaxin, predicts adverse outcome in patients with chronic heart failure. Eur Heart J 2003; 24: 61.

9 James SK, Lindahl B, Siegbahn A et al. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality andsubsequent myocardial infarction in patients with unstable coronary artery disease - a Global Utilization of Strategies to Open occluded arteries (GUSTO)-IV substudy. Circulation 2003; 108: 275-81. [OpenAIRE]

Umachandran V, Ranjadayalan K, Ambepityia G, Marchant B, Kopelman PG, Timmis AD. The Perception of angina in diabetes - relation to somatic pain threshold and autonomic function. Am Heart J 1991; 121: 1649-54.

Bruins S, Fokkema MR, Romer JWP et al. High intraindividual variation of B-type natriuretic peptide (BNP) and amino-terminal proBNP in patients with stable chronic heart failure. Clin Chem 2004; 50: 2052-58. [OpenAIRE]

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