Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

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Strawbridge, Rona; Dupuis, Josée; Prokopenko, Inga; Barker, Adam; Ahlqvist, Emma; Rybin, Denis; Petrie, John; Bouatia-Naji, Nabila; Dimas, Antigone; Wheeler, Eleanor; Chen, Han; Voight, Benjamin; Taneera, Jalal; Kanoni, Stavroula; Peden, John; Turrini, Fabiola; Gustafsson, Stefan; Zabena, Carina; Almgren, Peter; Dedoussis, George; Barnes, Daniel; Dennison, Elaine; Hagen, Knut; Eriksson, Per; Eury, Elodie; Folkersen, Lasse; Fox, Caroline; Frayling, Timothy; Goel, Anuj; Horikoshi, Momoko; ... view all 626 authors
(2011)
  • Subject:
    mesheuropmc: endocrine system | endocrine system diseases | nutritional and metabolic diseases

textabstractOBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing ... View more
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