publication . Article . 2016

Emergence of flagellar beating from the collective behavior of individual ATP-powered dyneins

S. Namdeo; Patrick Onck;
Open Access
  • Published: 10 Oct 2016 Journal: Physical Review E, volume 94 (issn: 2470-0045, eissn: 2470-0053, Copyright policy)
  • Publisher: American Physical Society (APS)
Flagella are hair-like projections from the surface of eukaryotic cells, and they play an important role in many cellular functions, such as cell-motility. The beating of flagella is enabled by their internal architecture, the axoneme, and is powered by a dense distribution of motor proteins, dyneins. The dyneins deliver the required mechanical work through the hydrolysis of ATP. Although the dynein-ATP cycle, the axoneme microstructure, and the flagellar-beating kinematics are well studied, their integration into a coherent picture of ATP-powered flagellar beating is still lacking. Here we show that a time-delayed negative-work-based switching mechanism is able...
free text keywords: HEADED PROCESSIVE MOTOR, SLIDING FILAMENT MODEL, SPERM FLAGELLA, SEA-URCHIN, FLEXURAL RIGIDITY, AXONEMAL DYNEIN, BEND PROPAGATION, MOLECULAR MOTORS, MECHANICAL-PROPERTIES, THERMAL FLUCTUATIONS, Microtubule, Nexin, biology.protein, biology, Motor protein, Biophysics, Flagellum, Nanotechnology, Axoneme, Molecular motor, Collective behavior, Physics, Dynein
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64 references, page 1 of 5

2 Lodish, H., A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore & J. Darnell, Molecular Cell Biology, 4th edition. W. H. Freeman, New York, 2000.

3 Burgess, S. A., M. L. Walker, H. Sakakibara, P. J. Knight & K. Oiwa, Dynein structure and power stroke. Nature, 421:715-18, 2003.

4 Burgess, S. A. & P. J. Knight, Is the dynein motor a winch? Current Opinion in Structural Biology, 14(2):138-146, 2004.

5 Hunt, A. J., Molecular motors: Keeping the beat. Nature, 393:624-625, 1998.

6 Ueno, H., T. Yasunaga, C. Shingyoji & K. Hirose, Dynein pulls microtubules without rotating its stalk. Proceedings of the National Academy of Sciences, 105(50):19702-19707, 2008.

7 Mitchison, T. J. & H. M. Mitchison, Cell biology: How cilia beat. Nature, 463:308-309, 2010. [OpenAIRE]

8 Lindemann, C. B. & K. A. Lesich, Flagellar and ciliary beating: the proven and the possible. Journal of Cell Science, 123(4):519-528, 2010. [OpenAIRE]

9 Brokaw, C. J., Thinking about flagellar oscillation. Cell Motil. Cytoskeleton, 66(8):425-436, 2009.

10 Camalet, S. & F. Ju¨licher, Generic aspects of axonemal beating. New Journal of Physics, 2(1):24, 2000.

12 Murase, M., Simulation of ciliary beating by an excitable dynein model: oscillations, quiescence and mechanosensitivity. J. Theor. Biol., 146(2):209-31, 1990.

13 Inaba, K., Sperm flagella: comparative and phylogenetic perspectives of protein components. Molecular Human Reproduction, 17(8):524-538, 2011.

14 Riedel-Kruse, I., A. Hilfinger, J. Howard & F. Ju¨licher, How molecular motors shape the flagellar beat. HFSP J., 1 (3):192-208, 2007.

15 Woolley, D. M., Flagellar oscillation: a commentary on proposed mechanisms. Biological Reviews, 85(3):453-470, 2010.

16 Machin, K. E., Wave propagation along flagella. J. Exp. Biol., 35:796-806, 1958. [OpenAIRE]

17 Lubliner, J. & J. Blum, Model for bend propagation in flagella. J. Theor. Biol., 31(1):1-24, 1971.

64 references, page 1 of 5
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