publication . Article . Other literature type . 2008 . Embargo end date: 05 Dec 2008

Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.

Sonuga-Barke, E J S; Lasky-Su, J; Neale, B M; Oades, R D; Chen, W; Franke, B; Buitelaar, J; Banaschewski, T; Ebstein, R; Gill, M; ...
Open Access
  • Published: 01 Jan 2008
  • Publisher: Wiley-Blackwell
Abstract
Studies of gene x environment (G x E) interaction in ADHD have previously focused on known risk genes for ADHD and environmentally mediated biological risk. Here we use G x E analysis in the context of a genome-wide association scan to identify novel genes whose effects on ADHD symptoms and comorbid conduct disorder are moderated by high maternal expressed emotion (EE). SNPs (600,000) were genotyped in 958 ADHD proband-parent trios. After applying data cleaning procedures we examined 429,981 autosomal SNPs in 909 family trios. ADHD symptom severity and comorbid conduct disorder was measured using the Parental Account of Childhood Symptoms interview. Maternal cri...
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Other literature type . 2008
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publication . Article . Other literature type . 2008 . Embargo end date: 05 Dec 2008

Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.

Sonuga-Barke, E J S; Lasky-Su, J; Neale, B M; Oades, R D; Chen, W; Franke, B; Buitelaar, J; Banaschewski, T; Ebstein, R; Gill, M; ...