Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan

Article English OPEN
Sonuga-Barke, E. ; Lasky-Su, J. ; Neale, B. ; Oades, R.D. ; Chen, W. ; Franke, B. ; Buitelaar, J.K. ; Banaschewski, T. ; Ebstein, R. ; Gill, M. ; Anney, R.J. ; Miranda, A. ; Mulas, F. ; Roeyers, H. ; Rothenberger, A. ; Sergeant, J.A. ; Steinhausen, H.C. ; Thompson, M. ; Asherson, P. ; Faraone, S.V. (2008)
  • Subject:
    mesheuropmc: mental disorders

Studies of gene x environment (G x E) interaction in ADHD have previously focused on known risk genes for ADHD and environmentally mediated biological risk. Here we use G x E analysis in the context of a genome-wide association scan to identify novel genes whose effects on ADHD symptoms and comorbid conduct disorder are moderated by high maternal expressed emotion (EE). SNPs (600,000) were genotyped in 958 ADHD proband-parent trios. After applying data cleaning procedures we examined 429,981 autosomal SNPs in 909 family trios. ADHD symptom severity and comorbid conduct disorder was measured using the Parental Account of Childhood Symptoms interview. Maternal criticism and warmth (i.e., EE) were coded by independent observers on comments made during the interview. No G x E interactions reached genome-wide significance. Nominal effects were found both with and without genetic main effects. For those with genetic main effects 36 uncorrected interaction P-values were <10
  • References (37)
    37 references, page 1 of 4

    Baker BL, Heller TL, Henker B. 2000. Expressed emotion, parenting stress, and adjustment in mothers of young children with behaviour problems. J Child Psychol Psychiatry 41:907-915.

    Baysal BE, Potkin SG, Farr JE, Higgins MJ, Korcz J, Gollin SM, James MR, Evans GA, Richard CW III. 1998. Bipolar affective disorder partially cosegregates with a balanced t(9;11)(p24;q23.1) chromosomal translocation in a small pedigree. Am J Med Genet 81:81-91.

    Becker K, El-Faddagh M, Schmidt MH, Esser G, Laucht M. 2008. Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms. J Pediatr 152:263-269.

    Benzel I, Bansal A, Browning BL, Galwey NW, Maycox PR, McGinnis R, Smart D, St Clair D, Yates P, Purvis I. 2007. Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia. Behav Brain Funct 3:31.

    Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Aneey R, Franke B, Gill M, Ebstein R, Buitelaar J, Sham P, Campbell D, Knight J, Andreou P, Altink M, Arnold R, Boer F, Buschgens C, Butler L, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriels I, Korn-Lubetzki I, Marco R, Medad S, Minderaa R, Mulas F, Muller U, Mulligan A, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Craig I, Banaschewski T, Sonuga-Barke E, Eisenberg J, Kuntsi J, Manor I, McGuffin PM, Miranda A, Oades RD, Plomin R, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, Asherson P, Johansson L. 2006a. The analysis of 52 candidate genes in DSM-VI combined subtype attention deficit hyperactivity disorder: Association signals in DRD4, DAT1 and 16 other genes. Mol Psych 11:934-953.

    Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen CK, Huang YS, Sethna V, Taylor E, Chen W, Breen G, Asherson P. 2006b. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63: 74-81.

    Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Puolton R. 2003. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301:386-389.

    Caspi A, Langley K, Milne B, Moffitt TE, O'Donovan M, Owen MJ, Tomas MP, Poulton R, Rutter M, Taylor A, Williams B, Thapar A. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 5:203-210.

    Chen W, Taylor E. 2006. PACS interview and genetic research of ADHD. In: Oades R, editor. Attention Deficit/Hyperactivity Disorder HKS: Current ideas and ways forward, 1st ed. New York: Nova Science Publishers, p. 3-20.

    Crosbie J, Perusse D, Barr CL, Schachar RJ. 2008. Validating psychiatric endophenotypes: Inhibitory control and attention deficit hyperactivity disorder. Neurosci Biobehav Rev 32:40-55.

  • Metrics
    No metrics available
Share - Bookmark

  • Download from
    DSpace at VU via NARCIS (Article, 2008)
  • Cite this publication