publication . Article . Other literature type . 2011

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies.

Herder, C.; Peeters, W.; Illig, T.; Baumert, J.; Kleijn, D. P.; Moll, F. L.; Poschen, U.; Klopp, N.; Müller-Nurasyid, M.; Roden, M.; ...
  • Published: 01 Jan 2011
Abstract
BACKGROUND: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. METHODS AND FINDINGS: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10....
Subjects
Medical Subject Headings: hemic and immune systems
free text keywords: Medizin, Adult; Aged; Animals; Atherosclerosis/blood; Calcinosis/blood; Case-Control Studies; Chemokine CCL5/blood; Cohort Studies; Coronary Disease/blood; Coronary Disease/diagnosis; Female; Follow-Up Studies; Germany; Humans; Macrophages/cytology; Male; Mice; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Risk, CARDIoGRAM Consortium, Macrophages, Animals, Humans, Mice, Coronary Disease, Calcinosis, Proportional Hazards Models, Risk, Case-Control Studies, Cohort Studies, Follow-Up Studies, Phenotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Germany, Female, Male, Atherosclerosis, Chemokine CCL5, General Science & Technology, Medicine, R, Science, Q, 610, Research Article, Anatomy and Physiology, Cardiovascular System, Cardiovascular, Cardiovascular Pharmacology, Myocardial Infarction, Clinical Immunology, Clinical Research Design, Epidemiology, Biomarker Epidemiology, Cardiovascular Disease Epidemiology, Clinical Epidemiology, ddc:610
58 references, page 1 of 4

Hansson, GK, Hermansson, A. The immune system in atherosclerosis.. Nat Immunol. 2011; 12: 204-212 [PubMed]

Libby, P. Inflammation in atherosclerosis.. Nature. 2008; 420: 868-874

Braunersreuther, V, Mach, F, Steffens, S. The specific role of chemokines in atherosclerosis.. Thromb Haemost. 2007; 97: 714-721 [OpenAIRE] [PubMed]

Aukrust, P, Halvorsen, B, Yndestad, A, Ueland, T, Oie, E. Chemokines and cardiovascular risk.. Arterioscler Thromb Vasc Biol. 2008; 28: 1909-1919 [OpenAIRE] [PubMed]

Zernecke, A, Shagdarsuren, E, Weber, C. Chemokines in atherosclerosis: an update.. Arterioscler Thromb Vasc Biol. 2008; 28: 1897-1908 [OpenAIRE] [PubMed]

Jones, KL, Maguire, JJ, Davenport, AP. Chemokine receptor CCR5: from AIDS to atherosclerosis.. Br J Pharmacol. 2011; 162: 1453-1469 [OpenAIRE] [PubMed]

Charo, IF, Ransohoff, RM. The many roles of chemokines and chemokine receptors in inflammation.. N Engl J Med. 2006; 354: 610-621 [OpenAIRE] [PubMed]

Appay, V, Rowland-Jones, SL. RANTES: a versatile and controversial chemokine.. Trends Immunol. 2001; 22: 83-87 [OpenAIRE] [PubMed]

Schall, TJ. Biology of the RANTES/SIS cytokine family.. Cytokine. 1991; 3: 165-183 [PubMed]

Alam, R, Stafford, S, Forsythe, P, Harrison, R, Faubion, D. RANTES is a chemotactic and activating factor for human eosinophils.. J Immunol. 1993; 150: 3442-3448 [PubMed]

Appay, V, Brown, A, Cribbes, S, Randle, E, Czaplewski, LG. Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants.. J Biol Chem. 1999; 274: 27505-27512 [OpenAIRE] [PubMed]

Ding, Z, Xiong, K, Issekutz, TB. Regulation of chemokine-induced transendothelial migration of T lymphocytes by endothelial activation: differential effects on naive and memory T cells.. J Leukoc Biol. 2000; 67: 825-833 [PubMed]

von Hundelshausen, P, Weber, KS, Huo, Y, Proudfoot, AE, Nelson, PJ. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium.. Circulation. 2001; 103: 1772-1777 [OpenAIRE] [PubMed]

Kameyoshi, Y, Dörschner, A, Mallet, AI, Christophers, E, Schröder, JM. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.. J Exp Med. 1992; 176: 587-592 [OpenAIRE] [PubMed]

Skurk, T, Mack, I, Kempf, K, Kolb, H, Hauner, H. Expression and secretion of RANTES (CCL5) in human adipocytes in response to immunological stimuli and hypoxia.. Horm Metab Res. 2009; 41: 183-189 [PubMed]

58 references, page 1 of 4
Abstract
BACKGROUND: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. METHODS AND FINDINGS: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10....
Subjects
Medical Subject Headings: hemic and immune systems
free text keywords: Medizin, Adult; Aged; Animals; Atherosclerosis/blood; Calcinosis/blood; Case-Control Studies; Chemokine CCL5/blood; Cohort Studies; Coronary Disease/blood; Coronary Disease/diagnosis; Female; Follow-Up Studies; Germany; Humans; Macrophages/cytology; Male; Mice; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Risk, CARDIoGRAM Consortium, Macrophages, Animals, Humans, Mice, Coronary Disease, Calcinosis, Proportional Hazards Models, Risk, Case-Control Studies, Cohort Studies, Follow-Up Studies, Phenotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Germany, Female, Male, Atherosclerosis, Chemokine CCL5, General Science & Technology, Medicine, R, Science, Q, 610, Research Article, Anatomy and Physiology, Cardiovascular System, Cardiovascular, Cardiovascular Pharmacology, Myocardial Infarction, Clinical Immunology, Clinical Research Design, Epidemiology, Biomarker Epidemiology, Cardiovascular Disease Epidemiology, Clinical Epidemiology, ddc:610
58 references, page 1 of 4

Hansson, GK, Hermansson, A. The immune system in atherosclerosis.. Nat Immunol. 2011; 12: 204-212 [PubMed]

Libby, P. Inflammation in atherosclerosis.. Nature. 2008; 420: 868-874

Braunersreuther, V, Mach, F, Steffens, S. The specific role of chemokines in atherosclerosis.. Thromb Haemost. 2007; 97: 714-721 [OpenAIRE] [PubMed]

Aukrust, P, Halvorsen, B, Yndestad, A, Ueland, T, Oie, E. Chemokines and cardiovascular risk.. Arterioscler Thromb Vasc Biol. 2008; 28: 1909-1919 [OpenAIRE] [PubMed]

Zernecke, A, Shagdarsuren, E, Weber, C. Chemokines in atherosclerosis: an update.. Arterioscler Thromb Vasc Biol. 2008; 28: 1897-1908 [OpenAIRE] [PubMed]

Jones, KL, Maguire, JJ, Davenport, AP. Chemokine receptor CCR5: from AIDS to atherosclerosis.. Br J Pharmacol. 2011; 162: 1453-1469 [OpenAIRE] [PubMed]

Charo, IF, Ransohoff, RM. The many roles of chemokines and chemokine receptors in inflammation.. N Engl J Med. 2006; 354: 610-621 [OpenAIRE] [PubMed]

Appay, V, Rowland-Jones, SL. RANTES: a versatile and controversial chemokine.. Trends Immunol. 2001; 22: 83-87 [OpenAIRE] [PubMed]

Schall, TJ. Biology of the RANTES/SIS cytokine family.. Cytokine. 1991; 3: 165-183 [PubMed]

Alam, R, Stafford, S, Forsythe, P, Harrison, R, Faubion, D. RANTES is a chemotactic and activating factor for human eosinophils.. J Immunol. 1993; 150: 3442-3448 [PubMed]

Appay, V, Brown, A, Cribbes, S, Randle, E, Czaplewski, LG. Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants.. J Biol Chem. 1999; 274: 27505-27512 [OpenAIRE] [PubMed]

Ding, Z, Xiong, K, Issekutz, TB. Regulation of chemokine-induced transendothelial migration of T lymphocytes by endothelial activation: differential effects on naive and memory T cells.. J Leukoc Biol. 2000; 67: 825-833 [PubMed]

von Hundelshausen, P, Weber, KS, Huo, Y, Proudfoot, AE, Nelson, PJ. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium.. Circulation. 2001; 103: 1772-1777 [OpenAIRE] [PubMed]

Kameyoshi, Y, Dörschner, A, Mallet, AI, Christophers, E, Schröder, JM. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.. J Exp Med. 1992; 176: 587-592 [OpenAIRE] [PubMed]

Skurk, T, Mack, I, Kempf, K, Kolb, H, Hauner, H. Expression and secretion of RANTES (CCL5) in human adipocytes in response to immunological stimuli and hypoxia.. Horm Metab Res. 2009; 41: 183-189 [PubMed]

58 references, page 1 of 4
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