publication . Article . 2002

Contribution of caffeine to the homocysteine-raising effect of coffee : a randomized controlled trial in humans

Verhoef, P.; Pasman, W.J.; Vliet, T. van; Urgert, R.; Katan, M.B.;
Open Access English
  • Published: 01 Jan 2002
Abstract
Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown. Objective: The objective was to determine whether caffeine explains the homocysteine-raising effect of coffee. Design: Forty-eight subjects aged 19-65 y completed this randomized crossover study with 3 treatments, each lasting 2 wk. Subjects consumed 6 capsules providing 870 mg caffeine/d (test treatment), 0.9 L paper-filtered coffee providing ≈870 mg caffeine/d, or 6 placebo capsules. Blood...
Subjects
free text keywords: Humane Voeding, Physics and Physical Chemistry of Foods, Paper-filtered coffee, Sex difference, Afdeling Humane voeding, Fasting, Amino acid metabolism, Leerstoelgroep Fysica en fysische chemie van levensmiddelen, Caffeine, Placebos, Human Nutrition, Dietary intake, Clinical article, Controlled clinical trial, Vitamin B 12, Cross-Over Studies, Female, Human, B vitamins, Homocysteine, Clinical trial, Diet restriction, Aged, Middle Aged, VLAG, Fysica en Fysische Chemie van Levensmiddelen, Human Nutrition (HNE), Randomized controlled trial, Sex Characteristics, Controlled study, Coffee, Humane Voeding & Gezondheid, Crossover procedure, Vitamin B 6, Human Nutrition & Health, Adult, Humans, Crossover experiment, Male
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publication . Article . 2002

Contribution of caffeine to the homocysteine-raising effect of coffee : a randomized controlled trial in humans

Verhoef, P.; Pasman, W.J.; Vliet, T. van; Urgert, R.; Katan, M.B.;