publication . Article . Other literature type . 2019

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

Nick A. Weaver; Thomas Doeven; Frederik Barkhof; J. Matthijs Biesbroek; Onno N. Groeneveld; Hugo J. Kuijf; Niels D. Prins; Philip Scheltens; Charlotte E. Teunissen; Wiesje M. van der Flier; ...
Open Access English
  • Published: 01 Dec 2019
Abstract
Abstract White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwis...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Alzheimer's disease, Amyloid-beta, Cerebrospinal fluid, Lesion mapping, Magnetic resonance imaging, Tau, White matter hyperintensities, Alzheimer's disease, Amyloid-beta, Cerebrospinal fluid, Lesion mapping, Magnetic resonance imaging, Tau, White matter hyperintensities, Clinical Neurology, Geriatrics and Gerontology, Ageing, Neuroscience(all), Developmental Biology, yes, Journal Article, General Neuroscience, Amyloid beta, biology.protein, biology, Psychology, Splenium, Pathology, medicine.medical_specialty, medicine, White matter, medicine.anatomical_structure, Internal medicine, Endocrinology, medicine.diagnostic_test, Hyperintensity, Amyloid, Corpus callosum
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publication . Article . Other literature type . 2019

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

Nick A. Weaver; Thomas Doeven; Frederik Barkhof; J. Matthijs Biesbroek; Onno N. Groeneveld; Hugo J. Kuijf; Niels D. Prins; Philip Scheltens; Charlotte E. Teunissen; Wiesje M. van der Flier; ...