publication . Article . Other literature type . 2008

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Macleod, Malcolm R.; van der Worp, H. Bart; Sena, Emily S.; Howells, David W.; Dirnagl, Ulrich; Donnan, Geoffrey A.;
Open Access
  • Published: 01 Oct 2008 Journal: Stroke, volume 39, pages 2,824-2,829 (issn: 0039-2499, eissn: 1524-4628, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
Background and Purpose-The neutral results of the SAINT II trial have again highlighted difficulties translating neuroprotective efficacy from bench to bedside. Animal studies are susceptible to study quality biases, which may lead to overstatement of efficacy. We report the impact of study quality on published estimates of the efficacy of NXY-059 in animal models of stroke. Methods-We conducted a systematic review and stratified meta-analysis of published studies describing the efficacy of NXY-059 in experimental focal cerebral ischemia. Results-Overall, NXY-059 improved infarct volume by 43.3% (95% CI, 34.7 to 52.8). Only 2 of 9 publications reported randomiza...
Subjects
free text keywords: Advanced and Specialised Nursing, Clinical Neurology, Cardiology and Cardiovascular Medicine, Stroke, medicine.disease, medicine, Intensive care medicine, medicine.medical_specialty, Animal studies, Randomization, Cerebral ischaemia, Physical therapy, Surgery, business.industry, business, Outcome assessment, MEDLINE, neuroprotection, NXY-059, study quality, TISSUE-PLASMINOGEN ACTIVATOR, OXIDE GENERIC NXY-059, EMBOLIC STROKE MODEL, SPIN TRAP AGENT, NEUROPROTECTIVE AGENTS, INFARCT VOLUME, ANIMAL-MODELS, METAANALYSIS, TRANSIENT, REPERFUSION
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publication . Article . Other literature type . 2008

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Macleod, Malcolm R.; van der Worp, H. Bart; Sena, Emily S.; Howells, David W.; Dirnagl, Ulrich; Donnan, Geoffrey A.;