publication . Article . 1993

In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour

Vrie, Wim; Gheuens, Eric; Durante, N.M.C.; Bruijn, Ernst; Marquet, Richard; Oosterom, Allan; Eggermont, Alexander;
Open Access English
  • Published: 01 Oct 1993
Abstract
textabstractColon tumours are intrinsically resistant to chemotherapy and most of them express the multidrug transporter P glycoprotein (Pgp). Whether this Pgp expression determines their resistance to anticancer agents in patients is not known. We report here on the reversibility of intrinsic multidrug resistance in a syngeneic, solid tumour model. CC531 is a rat colon carcinoma that expresses Pgp, as was shown with the monoclonal antibody C-219. In vitro the sensitivity to doxorubicin, daunorubicin and colchicine was enhanced by the addition of the chemosensitizers verapamil and cyclosporin A (CsA), while the sensitivity to cisplatin was not enhanced. In a dau...
Subjects
mesheuropmc: polycyclic compounds
free text keywords: Multidrug resistance, P glycoprotein, Cyclosporin A, In vivo, Chemosensitizing
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32 references, page 1 of 3

Boesch D, Gav6riaux C, Jachez B, Pourtier-Manzanedo A, Bollinger P, Loor F (1991a) In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res 51:4226-4233

Boesch D, Muller K, Pourtier-Mabzanedo A, Loor F (1991b) Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative. Exp Cell Res 196:26-32

Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47:936-942

Dalton WS, Grogan TM, Meltzer PS, Scheper RJ, Durie BGM, Taylor CW, Miller TP, Salmon SE (1989) Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol 7:415-424

Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84:265-269 [OpenAIRE]

Ford JM, Hait WN (1990) Pharmacology of drugs that alter multidrug restistance in cancer. Pharmacol Rev 42:155-199

Gav6riaux C, Boesch D, Boelsterli JJ, Bollinger P, Eberle MK, Hiestand P, Payne T, Traber R, Wenger R, Loot F (1989) Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppresive derivatives: Br J Cancer 60:867-871 [OpenAIRE]

Gheuens EEO, Van Bockstaele DR, Van der Keur M, Tanke HJ, Van Oosterom AT, De Bruijn EA (1991) Flow cytometric double labeling technique for screening of multidrug resistance. Cytometry 12:636-644 [OpenAIRE]

Goldstein LJ, Galski H, Fojo A, Willingham M, Lai S-L, Gazdar A, Pirker R, Green A, Crist W, Brodeur GM, Lieber M, Cossman J, Gottesman MM, Pastan I (1989) Expression of a multidrug resistance gene in human cancers. JNCI 81:116-124

Kanamaru H, Kakehi Y, Yoshida O, Nakanishi S, Pastan I, Gottesman MM (1989) MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants. JNCI 81:844-849

Kartner N, Evernden-Porelle DE, Bradley G, Ling V (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316:820-823

Kaye SB (1990) Reversal of multidrug resistance. Cancer Treat Rev 17 [Suppl A]:37-43

Los G, Nagel JD, McVie JG (1990) Anti-tumor effect of cisplatin, carboplatin, mitoxantrone, and doxorubicin on peritoneal tumor growth after intraperitoneal and intravenous chemotherapy: a comparative study. Sel Cancer Ther 6:73-82

Marquet RL, Westbroek DL, Jeekel J (1984) Interferon treatment of a transplantable rat colon adenocarcinoma: importance of tumor site. Int J Cancer 33:689-692

Meador J, Sweet P, Smpecky M, Wetzel M, Murray S, Gupta S, Slater L (1987) Enhancement by cyclosporin A of daunorubicin efficacy in Ehrlich ascites carcinoma and murine hepatoma 129. Cancer Res 47:6216-6219

32 references, page 1 of 3
Abstract
textabstractColon tumours are intrinsically resistant to chemotherapy and most of them express the multidrug transporter P glycoprotein (Pgp). Whether this Pgp expression determines their resistance to anticancer agents in patients is not known. We report here on the reversibility of intrinsic multidrug resistance in a syngeneic, solid tumour model. CC531 is a rat colon carcinoma that expresses Pgp, as was shown with the monoclonal antibody C-219. In vitro the sensitivity to doxorubicin, daunorubicin and colchicine was enhanced by the addition of the chemosensitizers verapamil and cyclosporin A (CsA), while the sensitivity to cisplatin was not enhanced. In a dau...
Subjects
mesheuropmc: polycyclic compounds
free text keywords: Multidrug resistance, P glycoprotein, Cyclosporin A, In vivo, Chemosensitizing
Download from
32 references, page 1 of 3

Boesch D, Gav6riaux C, Jachez B, Pourtier-Manzanedo A, Bollinger P, Loor F (1991a) In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res 51:4226-4233

Boesch D, Muller K, Pourtier-Mabzanedo A, Loor F (1991b) Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative. Exp Cell Res 196:26-32

Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47:936-942

Dalton WS, Grogan TM, Meltzer PS, Scheper RJ, Durie BGM, Taylor CW, Miller TP, Salmon SE (1989) Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol 7:415-424

Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84:265-269 [OpenAIRE]

Ford JM, Hait WN (1990) Pharmacology of drugs that alter multidrug restistance in cancer. Pharmacol Rev 42:155-199

Gav6riaux C, Boesch D, Boelsterli JJ, Bollinger P, Eberle MK, Hiestand P, Payne T, Traber R, Wenger R, Loot F (1989) Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppresive derivatives: Br J Cancer 60:867-871 [OpenAIRE]

Gheuens EEO, Van Bockstaele DR, Van der Keur M, Tanke HJ, Van Oosterom AT, De Bruijn EA (1991) Flow cytometric double labeling technique for screening of multidrug resistance. Cytometry 12:636-644 [OpenAIRE]

Goldstein LJ, Galski H, Fojo A, Willingham M, Lai S-L, Gazdar A, Pirker R, Green A, Crist W, Brodeur GM, Lieber M, Cossman J, Gottesman MM, Pastan I (1989) Expression of a multidrug resistance gene in human cancers. JNCI 81:116-124

Kanamaru H, Kakehi Y, Yoshida O, Nakanishi S, Pastan I, Gottesman MM (1989) MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants. JNCI 81:844-849

Kartner N, Evernden-Porelle DE, Bradley G, Ling V (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316:820-823

Kaye SB (1990) Reversal of multidrug resistance. Cancer Treat Rev 17 [Suppl A]:37-43

Los G, Nagel JD, McVie JG (1990) Anti-tumor effect of cisplatin, carboplatin, mitoxantrone, and doxorubicin on peritoneal tumor growth after intraperitoneal and intravenous chemotherapy: a comparative study. Sel Cancer Ther 6:73-82

Marquet RL, Westbroek DL, Jeekel J (1984) Interferon treatment of a transplantable rat colon adenocarcinoma: importance of tumor site. Int J Cancer 33:689-692

Meador J, Sweet P, Smpecky M, Wetzel M, Murray S, Gupta S, Slater L (1987) Enhancement by cyclosporin A of daunorubicin efficacy in Ehrlich ascites carcinoma and murine hepatoma 129. Cancer Res 47:6216-6219

32 references, page 1 of 3
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