In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour

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Vrie, Wim; Gheuens, Eric; Durante, N.M.C.; Bruijn, Ernst; Marquet, Richard; Oosterom, Allan; Eggermont, Alexander;
(1993)
  • Subject: Multidrug resistance | P glycoprotein | Cyclosporin A | In vivo | Chemosensitizing
    mesheuropmc: polycyclic compounds

textabstractColon tumours are intrinsically resistant to chemotherapy and most of them express the multidrug transporter P glycoprotein (Pgp). Whether this Pgp expression determines their resistance to anticancer agents in patients is not known. We report here on the re... View more
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