In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour

Article English OPEN
Vrie, Wim; Gheuens, Eric; Durante, N.M.C.; Bruijn, Ernst; Marquet, Richard; Oosterom, Allan; Eggermont, Alexander;
  • Subject: Multidrug resistance | P glycoprotein | Cyclosporin A | In vivo | Chemosensitizing
    mesheuropmc: polycyclic compounds

textabstractColon tumours are intrinsically resistant to chemotherapy and most of them express the multidrug transporter P glycoprotein (Pgp). Whether this Pgp expression determines their resistance to anticancer agents in patients is not known. We report here on the re... View more
Share - Bookmark