Increased Incidence of T-Cell Malignancies in Patients with Chronic Lymphocytic Leukemia

Article English OPEN
Choi, Goda ; van den Broek, Esther C ; Stam, Olga CG ; van Noesel, C.J.M. ; Tonino, Sanne H. ; Kater, Armon P. (2015)
  • Subject:
    mesheuropmc: hemic and lymphatic diseases | immune system diseases | neoplasms

We present a patient with chemotherapy-refractory Chronic Lymphocytic Leukemia (CLL) in whom postmortem examination showed hepatosplenomegaly, with both multiple small-cellular CLL lesions and large-cellular, monoclonal T-cell infiltrates. Following this case, the co-incidence of T-cell malignancies and CLL was studied using Dutch and American cancer registry databases. Analysis showed an excess risk for T-cell malignancies in CLL patients, with increased standardized incidence ratios compared with the general population and all cancer survivors in the databases. We hypothesize that CLL cells interact with T-cells in the microenvironment, facilitating malignant transformation
  • References (16)
    16 references, page 1 of 2

    1. Wierda WG, O'Brien S, Wang X, Faderl S, Ferrajoli A, Do KA, Garcia-Manero G . Characteristics associated with important clinical end points in patients with chronic lymphocytic leukemia at initial treatment. J Clin Oncol. 2009; 27: 1637-1643.

    2. Molica S. Second neoplasms in chronic lymphocytic leukemia: incidence and pathogenesis with emphasis on the role of different therapies. Leuk Lymphoma. 2005; 46: 49-54.

    3. Beiggi S, Johnston JB, Seftel MD, Pitz MW, Kumar R, Banerji V, et al. Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study. Br J Cancer. 2013; 109: 1287-1290.

    4. Burger JA. Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2011; 2011: 96-103.

    5. Rossi D, Gaidano G. Richter syndrome: molecular insights and clinical perspectives. Hematol Oncol. 2009; 27: 1-10.

    6. Brecher M, Banks PM. Hodgkin's disease variant of Richter's syndrome. Report of eight cases. Am J Clin Pathol. 1990; 93: 333-339.

    7. Fayad L, Robertson LE, O'Brien S, Manning JT, Wright S, Hagemeister F, et al. Hodgkin's disease variant of Richter's syndrome: experience at a single institution. Leuk Lymphoma. 1996; 23: 333-337.

    8. Weisenberg E, Anastasi J, Adeyanju M, Variakojis D, Vardiman JW. Hodgkin's disease associated with chronic lymphocytic leukemia. Eight additional cases, including two of the nodular lymphocyte predominant type. Am J Clin Pathol. 1995; 103: 479-484.

    9. Lee A, Skelly ME, Kingma DW, Medeiros LJ. B-cell chronic lymphocytic leukemia followed by high grade T-cell lymphoma. An unusual variant of Richter's syndrome. Am J Clin Pathol. 1995; 103: 348-352.

    10. Martinez A, Pittaluga S, Villamor N, Colomer D, Rozman M, Raffeld M, et al. Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysis. Am J Surg Pathol. 2004; 28: 849-858.

  • Metrics
    No metrics available
Share - Bookmark