publication . Other literature type . Article . 2010

Spin-Echo Small Angle Neutron Scattering analysis of liposomes and bacteria

Léon F van Heijkamp; Ana-Maria Sevcenco; Diane Abou; Remko van Luik; Gerard C Krijger; Peter-Leon Hagedoorn; Ignatz M de Schepper; Bert Wolterbeek; Gerben A Koning; Wim G Bouwman;
  • Published: 01 Oct 2010
  • Publisher: IOP Publishing
  • Country: Netherlands
Abstract
Two types of liposomes, commonly used in drug delivery studies, and E. coli bacteria, all prepared in H2O, were resuspended in D2O and measured with Small Angle Spin-Echo Neutron Scattering (SESANS). Modeling was performed using correlation functions for solid spheres and hollow spheres. The signal strength and curve shape were more indicative of hollow particles, indicating that the H2O-D2O exchange occurred too fast to be observed with the available time resolution. Fitting the particle diameter and membrane thickness of the hollow sphere model to the data, gave results which were in good agreement with Dynamic Light Scattering (DLS) data and literature, showi...
Subjects
free text keywords: Spin echo, SPHERES, Intracellular vesicle, Analytical chemistry, Dynamic light scattering, Neutron scattering, Chemistry, Membrane, Chemical physics, Transport phenomena, Small-angle neutron scattering
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publication . Other literature type . Article . 2010

Spin-Echo Small Angle Neutron Scattering analysis of liposomes and bacteria

Léon F van Heijkamp; Ana-Maria Sevcenco; Diane Abou; Remko van Luik; Gerard C Krijger; Peter-Leon Hagedoorn; Ignatz M de Schepper; Bert Wolterbeek; Gerben A Koning; Wim G Bouwman;