Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

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Speliotes, E.K.; Yerges-Armstrong, L.M.; Wu, J.; Hernaez, R.; Kim, L.J.; Palmer, C.D.; Gudnason, V.; Eiriksdottir, G.; Garcia, M.E.; Launer, L.J.; Nalls, M.A.; Clark, J.M.; Mitchell, B.D.; Shuldiner, A.R.; Butler, J.L.; Tomas, M.; Hoffmann, U.; Hwang, S.J.; Massaro, J.M.; O'Donnell, C.J.; Sahani, D.V.; Salomaa, V.; Schadt, E.E.; Schwartz, S.M.; Siscovick, D.S.; Voight, B.F.; Carr, J.J.; Feitosa, M.F.; Harris, T.B.; Fox, C.S.; ... view all 36 authors

Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomog... View more