Aggregation and toxicity of amyloid-beta peptide in relation to peptide sequence variation

Doctoral thesis English OPEN
Vandersteen, A.;
  • Publisher: Universiteit Twente
  • Subject: METIS-288677 | IR-81970

Generally, aggregation of the amyloid-ß peptide is considered the cause of neuronal death in Alzheimer disease. The heterogenous Aß peptide occurs in various lengths in vivo: Aß40 and Aß42 are the predominant forms while both shorter and longer peptides exist. Aß40 and ... View more
  • References (63)
    63 references, page 1 of 7

    [1] Lambert M, Barlow A, Chromy B, Edwards C, Freed R, Liosatos M, Morgan T, Rozovsky I, Trommer B, Viola K, Wals P, Zhang C, Finch C, Krafft G, Klein W (1998). Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA, 95:6448- 6453.

    [2] Hoyer W, Antony T, Cherny D, Heim G, Jovin T, Subramaniam V (2002). Dependence of α-synuclein aggregate morphology on solution conditions. J. Mol. Biol., 322:383-393.

    [3] Bitan G, Kirkitadze M, Lomakin A, Vollers S, Benedek G, Teplow D (2003). Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proc. Natl. Acad. Sci. USA, 100:330-335.

    [4] Hepler R, Grimm K, Nahas D, Breese R, Dodson E, Acton P, Keller P, Yeager M, Wang H, Shugrue P, Kinney G, Joyce J (2006). Solution state characterization of amyloid β-derived diffusible ligands. Biochemistry, 45:15157-15167.

    [5] Lesné S, Koh M, Kotilinek L, Kayed R, Glabe C, Yang A (2006). A specific amyloid-β protein assembly in the brain impairs memory. Nature, 440:352-357.

    [6] Jarrett J, Berger E, Lansbury P (1993). The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochem., 32:4693-4697.

    [7] Jarrett J & Lansbury P (1993). Seeding one-dimensional crystallization of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell, 73:1055-1058.

    [8] Snyder S, Ladror U, Wade W, Wang G, Barrett L, Matayoshi E, Huffaker H, Krafft G, Holzman T (1994). Amyloid-β aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophys. J., 67:1216-1228.

    [9] Johansson A, Berglind-Dehlin F, Karlsson G, Edwards K, Gellerfors P, Lannfelt L (2006). Physiochemical characterization of the Alzheimer's disease-related peptides Aβ1-42 Arctic and Aβ1-42 wt. FEBS. J., 273:2618-2630.

    [10] Kelly S, Jess T, Price N (2005). How to study proteins by circular dichroism. Biochim. Biophys. Acta, 1751:119-139.

  • Similar Research Results (3)
  • Bioentities (4)
    1ary Protein Data Bank
    2ary Protein Data Bank
    3ary Protein Data Bank
    4ary Protein Data Bank
  • Metrics
    No metrics available
Share - Bookmark