publication . Article . 2009

No evidence for systemic platelet activation during or after orthotopic liver transplantation.

Ilona T. A. Pereboom; Jelle Adelmeijer; Yvonne van Leeuwen; Herman G. D. Hendriks; Robert J. Porte; Ton Lisman;
Restricted English
  • Published: 01 Aug 2009
Abstract
Platelet function is thought to deteriorate during liver transplantation as a result of platelet activation and proteolysis of platelet receptors by plasmin following reperfusion. However, this hypothesis has never been formally tested. Twenty patients undergoing a first or second liver transplant were included in the study. Blood samples were taken at standardized time points during transplantation and up to 10 days after transplantation. Platelet activation was assessed by detection of the activation markers P-selectin and activated integrin alpha IIb beta 3 with flow cytometry. Proteolytic cleavage of platelet receptors was assessed by flow cytometry measurem...
Subjects
free text keywords: TISSUE PLASMINOGEN-ACTIVATOR, BETA-THROMBOGLOBULIN, THROMBIN GENERATION, P-SELECTIN, CIRRHOSIS, DISEASE, COAGULATION, HEMOSTASIS, EXPRESSION, PATHOPHYSIOLOGY, UMCG Approved, Hepatology, Surgery, Transplantation, Liver transplantation, medicine.medical_treatment, medicine, Receptor, Platelet, Endocrinology, medicine.medical_specialty, Immunology, Intensive care medicine, Platelet factor 4, Internal medicine, business.industry, business
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